Evidence map›Paper›PMID 32685096›Full record

ArticleOxidative medicine and cellular longevity2020

Drp-1 as Potential Therapeutic Target for Lipopolysaccharide-Induced Vascular Hyperpermeability.

Xu Luo, Shumin Cai, Yunfeng Li, Guicheng Li, Yuanyuan Cao, Chenmu Ai, Youguang Gao, Tao Li

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Xu LuoDepartment of Critical Care Medicine, The People's Hospital of Longhua, Shenzhen 518109, China.
Shumin CaiDepartment of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Yunfeng LiDepartment of Critical Care Medicine, The First People's Hospital of Chenzhou, Affiliated Chenzhou Hospital, Southern Medical University, Chenzhou 423000, China.
Guicheng LiDepartment of Critical Care Medicine, The First People's Hospital of Chenzhou, Affiliated Chenzhou Hospital, Southern Medical University, Chenzhou 423000, China.
Yuanyuan CaoDepartment of Critical Care Medicine, The First People's Hospital of Chenzhou, Affiliated Chenzhou Hospital, Southern Medical University, Chenzhou 423000, China.
Chenmu AiDepartment of Critical Care Medicine, The First People's Hospital of Chenzhou, Affiliated Chenzhou Hospital, Southern Medical University, Chenzhou 423000, China.
Youguang GaoDepartment of Anesthesiology, The First Affiliated Hospital of Fujian Medical University, The First School of Clinical Medicine, Fujian Medical University, Fuzhou 350005, China.ORCID https://orcid.org/0000-0002-4861-8825
Tao LiDepartment of Critical Care Medicine, The First People's Hospital of Chenzhou, Affiliated Chenzhou Hospital, Southern Medical University, Chenzhou 423000, China.ORCID https://orcid.org/0000-0001-8850-5836
Chenzhou First People's Hospital · CNFujian Medical University · CNNanfang Hospital · CNShenZhen People’s Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondria-dependent apoptotic signaling has a critical role in the pathogenesis of vascular hyperpermeability (VH). Dynamin-related protein-1- (Drp-1-) mediated mitochondrial fission plays an important role in mitochondrial homeostasis. In the present study, we studied the involvement of Drp-1 in resistance to VH induced by lipopolysaccharide (LPS). To establish the model of LPS-induced VH, LPS at 15 mg/kg was injected into rats

Indexed as

AnimalsCapillary PermeabilityDeath-Associated Protein KinasesDisease Models, AnimalHumansLipopolysaccharidesMaleRatsRats, Sprague-DawleyTransfectionDeath-Associated Protein KinasesLipopolysaccharides

Identifiers

PMID32685096
PMCPMC7336239
OpenAlexW3037669419

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.