Evidence map›Paper›PMID 32685059›Full record

ArticleDisease markers2020

Association Study of Coronary Artery Disease-Associated Genome-Wide Significant SNPs with Coronary Stenosis in Pakistani Population.

Asma Naseer Cheema, Dilek Pirim, Xingbin Wang, Jabar Ali, Attya Bhatti, Peter John, Eleanor Feingold, F Yesim Demirci, M Ilyas Kamboh

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease markers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Bangladeshi Atherosclerosis Biobank and Hub: The BANGABANDHU Study.International journal of general medicine · 2024
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Asma Naseer CheemaAtta-Ur-Rahman School of Applied Biosciences, National University of Sciences & Technology, H/12, Islamabad, Pakistan.ORCID https://orcid.org/0000-0002-9239-7601
Dilek PirimBursa Uludag University, Faculty of Arts and Sciences, Department of Molecular Biology and Genetics, Bursa, Turkey.ORCID https://orcid.org/0000-0002-0522-9432
Xingbin WangDepartment of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA.ORCID https://orcid.org/0000-0002-8530-0760
Jabar AliDepartment of Cardiology, Lady Reading Hospital, Peshawar, Pakistan.
Attya BhattiAtta-Ur-Rahman School of Applied Biosciences, National University of Sciences & Technology, H/12, Islamabad, Pakistan.ORCID https://orcid.org/0000-0002-2781-5221
Peter JohnAtta-Ur-Rahman School of Applied Biosciences, National University of Sciences & Technology, H/12, Islamabad, Pakistan.
Eleanor FeingoldDepartment of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA.
F Yesim DemirciDepartment of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA.
M Ilyas KambohDepartment of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA.ORCID https://orcid.org/0000-0002-3453-1438
University of Pittsburgh · USNational University of Sciences and Technology · PKBursa Uludağ Üni̇versi̇tesi̇ · TRInstitute of Child Health · INLady Reading Hospital · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genome-wide association studies (GWAS) of coronary artery disease (CAD) have revealed multiple genetic risk loci. We assessed the association of 47 genome-wide significant single-nucleotide polymorphisms (SNPs) at 43 CAD loci with coronary stenosis in a Pakistani sample comprising 663 clinically ascertained and angiographically confirmed cases. Genotypes were determined using the iPLEX Gold technology. All statistical analyses were performed using R software. Linkage disequilibrium (LD) between significant SNPs was determined using SNAP web portal, and functional annotation of SNPs was performed using the RegulomeDB and Genotype-Tissue Expression (GTEx) databases. Genotyping comparison was made between cases with severe stenosis (≥70%) and mild/minimal stenosis (<30%). Five SNPs demonstrated significant associations: three with additive genetic models

Indexed as

Polymorphism, Single NucleotideAdultAgedCell Adhesion MoleculesCoronary Artery DiseaseCoronary StenosisFemaleGenome-Wide Association StudyHumansMaleMiddle AgedOrganic Cation Transporter 3Organic Cation Transport ProteinsPakistanQuantitative Trait LociUbiquitin-Conjugating EnzymesCell Adhesion MoleculesJCAD protein, humanOrganic Cation Transporter 3Organic Cation Transport ProteinsUBE2Z protein, humanUbiquitin-Conjugating Enzymes

Identifiers

PMID32685059
PMCPMC7336215
OpenAlexW3037989600

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.