Evidence map›Paper›PMID 32685030›Full record

ArticleTheranostics2020

Engineering Circulating Tumor Cells as Novel Cancer Theranostics.

Katie M Parkins, Veronica P Dubois, John J Kelly, Yuanxin Chen, Natasha N Knier, Paula J Foster, John A Ronald

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Katie M ParkinsRobarts Research Institute, The University of Western Ontario, London, Ontario, Canada.
Veronica P DuboisRobarts Research Institute, The University of Western Ontario, London, Ontario, Canada.
John J KellyRobarts Research Institute, The University of Western Ontario, London, Ontario, Canada.
Yuanxin ChenRobarts Research Institute, The University of Western Ontario, London, Ontario, Canada.
Natasha N KnierRobarts Research Institute, The University of Western Ontario, London, Ontario, Canada.
Paula J FosterRobarts Research Institute, The University of Western Ontario, London, Ontario, Canada.
John A RonaldRobarts Research Institute, The University of Western Ontario, London, Ontario, Canada.
Robarts Clinical Trials · CAWestern University · CALawson Health Research Institute · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

New ways to target and treat metastatic disease are urgently needed. Tumor "self-homing" describes the recruitment of circulating tumor cells (CTCs) back to a previously excised primary tumor location, contributing to tumor recurrence, as well as their migration to established metastatic lesions. Recently, self-homing CTCs have been exploited as delivery vehicles for anti-cancer therapeutics in preclinical primary tumor models. However, the ability of CTCs to self-home and treat metastatic disease is largely unknown.

Indexed as

Neoplastic Cells, CirculatingAnimalsAntineoplastic AgentsCell EngineeringCell Line, TumorDisease Models, AnimalDrug Delivery SystemsFemaleGenes, ReporterGenetic TherapyHumansIntravital MicroscopyLuminescent AgentsMammary Neoplasms, ExperimentalMiceNeoplasmsAntineoplastic AgentsLuminescent AgentsProdrugsCTCdrug deliverymetastasisself-homingself-targeted therapy

Identifiers

PMID32685030
PMCPMC7359075
OpenAlexW3039452644

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.