Evidence map›Paper›PMID 32685005›Full record

ArticleTheranostics2020

Exosomes-mediated Transfer of miR-125a/b in Cell-to-cell Communication: A Novel Mechanism of Genetic Exchange in the Intestinal Microenvironment.

Wei Cheng, Kai Wang, Zhenguo Zhao, Qi Mao, Gang Wang, Qiurong Li, Zheng Fu, Zhiwei Jiang, Jian Wang, Jieshou Li

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

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  6. Posttranscriptional Regulation of Intestinal Mucosal Growth and Adaptation by Noncoding RNAs in Critical Surgical Disorders.Journal of investigative surgery : the official journal of the Academy of Surgical Research · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Wei ChengResearch Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210000, China.
Kai WangDepartment of General Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221000, People's Republic of China.
Zhenguo ZhaoDepartment of General Surgery, Jiangyin Hospital Affiliated to Nantong University, Jiangyin, Jiangsu, 214400, People's Republic of China.
Qi MaoResearch Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210000, China.
Gang WangDepartment of General Surgery, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210000, China.
Qiurong LiResearch Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210000, China.
Zheng FuState Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, School of Life Sciences, NJU Advanced Institute for Life Sciences, Nanjing University, Nanjing, 210000, China.
Zhiwei JiangDepartment of General Surgery, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210000, China.
Jian WangResearch Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210000, China.
Jieshou LiResearch Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210000, China.
Jiangsu Province Hospital · CNNanjing University of Chinese Medicine · CNXuzhou Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glucagon-like peptide-2 (GLP-2), a key factor in intestinal rehabilitation therapy of short bowel syndrome (SBS), may require cell-to-cell communication to exert its biological functions. However, understanding of the mechanism remains elusive. Here, we report participation of exosomal miR-125a/b in GLP-2 mediated intestinal epithelial cells-myofibroblasts cross-talk in intestinal microenvironment.

Indexed as

AnimalsApoptosisCell CommunicationCell LineCell ProliferationCoculture TechniquesDisease Models, AnimalDown-RegulationEpithelial CellsExosomesGene Knockdown TechniquesGlucagon-Like Peptide 2HumansIntestinal MucosaMaleMicroRNAsGlucagon-Like Peptide 2MCL1 protein, humanMcl1 protein, ratMicroRNAsMIRN125 microRNA, humanMIRN125 microRNA, ratMyeloid Cell Leukemia Sequence 1 ProteinExosomesGlucagon-like peptide-2miR-125a/bProliferation and apoptosis of intestinal epithelial cellsShort bowel syndrome

Identifiers

PMID32685005
PMCPMC7359098
OpenAlexW3039294021

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.