Evidence map›Paper›PMID 32684973›Full record

ArticleEvolutionary applications2020

Applied phyloepidemiology: Detecting drivers of pathogen transmission from genomic signatures using density measures.

Thierry Wirth, Vanessa Wong, François Vandenesch, Jean-Philippe Rasigade

Open access · goldAbstract read
In one paragraph

Article in Evolutionary applications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

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  4. Markers of epidemiological success of methicillin-resistant Staphylococcus aureus isolates in European populations.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Thierry WirthInstitut de Systématique, Evolution, Biodiversité UMR-CNRS 7205 Muséum National d'Histoire Naturelle Université Pierre et Marie Curie Université des Antilles Ecole Pratique des Hautes Etudes Sorbonne Universités Paris France.ORCID https://orcid.org/0000-0002-7371-0172
Vanessa WongCambridge Institute for Medical Research Welcome Trust Center Cambridge UK.
François VandeneschCIRI INSERM U1111 CNRS UMR5308 ENS Lyon University of Lyon Lyon France.
Jean-Philippe RasigadeCIRI INSERM U1111 CNRS UMR5308 ENS Lyon University of Lyon Lyon France.ORCID https://orcid.org/0000-0002-8264-0452
Université Claude Bernard Lyon 1 · FRCentre National de la Recherche Scientifique · FRWellcome/MRC Cambridge Stem Cell Institute · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding the driving forces of an epidemic is key to inform intervention strategies against it. Correlating measures of the epidemic success of a pathogen with ancillary parameters such as its drug resistance profile provides a flexible tool to identify such driving forces. The recently described time-scaled haplotypic density (THD) method facilitates the inference of a pathogen's epidemic success from genetic data. Contrary to demogenetic approaches that define success in an aggregated fashion, the THD computes an independent index of success for each isolate in a collection. Modeling this index using multivariate regression, thus, allows us to control for various sources of bias and to identify independent predictors of success. We illustrate the use of THD to address key questions regarding three exemplary epidemics of multidrug-resistant (MDR) bacterial lineages, namely

Indexed as

epidemicfitness costfluoroquinolone resistanceSalmonellaStaphylococcusTHDtuberculosis

Identifiers

PMID32684973
PMCPMC7359849
OpenAlexW3022836549

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.