ArticleEvolutionary applications2020
The power and limitations of gene expression pathway analyses toward predicting population response to environmental stressors.
Article in Evolutionary applications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Problems With GO Enrichment as an Endpoint for Ecological Omics Interpretation.Molecular ecology · 2026Article
- Mild Warming Induces Divergent Plastic Responses in Gene Expression Among Populations of a Temperate Butterfly.Molecular ecology · 2026Article
- NOVAGene: a nonlinear approach to improve biological resolution in weighted gene co-expression networks for low-variability datasets.Frontiers in bioinformatics · 2026Article
- Characterizing genetic adaptations and plastic stress responses within a transcontinental North American keystone species.Tree physiology · 2025Article
- From whole bodies to single cells: A guide to transcriptomic approaches for ecology and evolutionary biology.Molecular ecology · 2025Review
- Asymmetric Micro-Evolutionary Responses in a Warming World: Heat-Driven Adaptation Enhances Metal Tolerance in a Planktonic Rotifer, but Not Vice Versa.Global change biology · 2025Article
- The interplay between epigenomic and transcriptomic variation during ecotype divergence in stickleback.BMC biology · 2025Article
- Metabolic differentiation of brushtail possum populations resistant and susceptible to plant toxins revealed via differential gene expression.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2025Article
- A Natural Hybrid Zone of Swordtails Reveals Molecular Insights Into the Adaptive Genomic Basis of Thermal Tolerance.Molecular ecology · 2024Article
- The master regulator OxyR orchestrates bacterial oxidative stress response genes in space and time.Cell systems · 2024Article
- E.PathDash, pathway activation analysis of publicly available pathogen gene expression data.mSystems · 2024Article
- Comparative Transcriptomic Reveals Greater Similarities in Response to Temperature Than to Invasive Alien Predator in the DamselflyEvolutionary applications · 2024Article
- MICROPHERRET: MICRObial PHEnotypic tRait ClassifieR using Machine lEarning Techniques.Environmental microbiome · 2024Article
- Title-Evaluation of Interplay of Gene Expression and Chromosome Structure in E. coli Growth: Regulatory Insights.Current microbiology · 2024Article
- Identification and validation of a novel risk model based on cuproptosis‑associated m6A for head and neck squamous cell carcinoma.BMC medical genomics · 2024Article
- PRANA: an R package for differential co-expression network analysis with the presence of additional covariates.BMC genomics · 2023Article
- Ex vivo exposures to arsenite and its methylated trivalent metabolites alter gene transcription in mouse sperm cells.Toxicology and applied pharmacology · 2022Article
- Mitochondrial volume density and evidence for its role in adaptive divergence in response to thermal tolerance in threespine stickleback.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Article
- The power and limitations of gene expression pathway analyses toward predicting population response to environmental stressors.Evolutionary applications · 2020Article
- From the woods to the halls of science: Louis Bernatchez's contributions to science, wildlife conservation and people.Evolutionary applications · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rapid environmental changes impact the global distribution and abundance of species, highlighting the urgency to understand and predict how populations will respond. The analysis of differentially expressed genes has elucidated areas of the genome involved in adaptive divergence to past and present environmental change. Such studies however have been hampered by large numbers of differentially expressed genes and limited knowledge of how these genes work in conjunction with each other. Recent methods (broadly termed "pathway analyses") have emerged that aim to group genes that behave in a coordinated fashion to a factor of interest. These methods aid in functional annotation and uncovering biological pathways, thereby collapsing complex datasets into more manageable units, providing more nuanced understandings of both the organism-level effects of modified gene expression, and the targets of adaptive divergence. Here, we reanalyze a dataset that investigated temperature-induced changes in gene expression in marine-adapted and freshwater-adapted threespine stickleback (
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