Evidence map›Paper›PMID 32684923›Full record

ArticleNeural plasticity2020

Functional Evolving Patterns of Cortical Networks in Progression of Alzheimer's Disease: A Graph-Based Resting-State fMRI Study.

Wei Li, Wen Wen, Xi Chen, BingJie Ni, Xuefeng Lin, Wenliang Fan, The Alzheimer's Disease Neuroimaging Initiative

Abstract read
In one paragraph

Article in Neural plasticity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wei LiThe School of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan 430074, China.
Wen WenThe School of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan 430074, China.
Xi ChenThe School of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan 430074, China.
BingJie NiThe School of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan 430074, China.
Xuefeng LinThe School of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan 430074, China.
Wenliang FanDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.ORCID 0000-0001-8949-6775
The Alzheimer's Disease Neuroimaging InitiativeAlzheimer's Disease Neuroimaging Initiative Study, USA.

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

AD is a common chronic progressive neurodegenerative disorder. However, the understanding of the dynamic longitudinal change of the brain in the progression of AD is still rough and sometimes conflicting. This paper analyzed the brain networks of healthy people and patients at different stages (EMCI, LMCI, and AD). The results showed that in global network properties, most differences only existed between healthy people and patients, and few were discovered between patients at different stages. However, nearly all subnetwork properties showed significant differences between patients at different stages. Moreover, the most interesting result was that we found two different functional evolving patterns of cortical networks in progression of AD, named 'temperature inversion' and "monotonous decline," but not the same monotonous decline trend as the external functional assessment observed in the course of disease progression. We suppose that those subnetworks, showing the same functional evolving pattern in AD progression, may have something the same in work mechanism in nature. And the subnetworks with 'temperature inversion' evolving pattern may play a special role in the development of AD.

Indexed as

AgedAged, 80 and overAlzheimer DiseaseBrain MappingCerebral CortexDisease ProgressionFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNerve Net

Identifiers

PMID32684923
PMCPMC7341396

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.