Evidence map›Paper›PMID 32684836›Full record

ArticleMediators of inflammation2020

Suppressors of Cytokine Signaling (SOCS)1 and SOCS3 Proteins Are Mediators of Interleukin-10 Modulation of Inflammatory Responses Induced by

Skyla A Duncan, Rajnish Sahu, Saurabh Dixit, Shree R Singh, Vida A Dennis

Open access · goldAbstract read
In one paragraph

Article in Mediators of inflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Enhanced Bioactivity ofFood science & nutrition · 2026
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  12. FABP4 activates the JAK2/STAT2 pathway via Rap1a in the homocysteine-induced macrophage inflammatory response in ApoELaboratory investigation; a journal of technical methods and pathology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Skyla A DuncanCenter for NanoBiotechnology Research (CNBR), Department of Biological Sciences, Alabama State University, 1627 Harris Way, Montgomery, AL 36104, USA.
Rajnish SahuCenter for NanoBiotechnology Research (CNBR), Department of Biological Sciences, Alabama State University, 1627 Harris Way, Montgomery, AL 36104, USA.
Saurabh DixitCenter for NanoBiotechnology Research (CNBR), Department of Biological Sciences, Alabama State University, 1627 Harris Way, Montgomery, AL 36104, USA.ORCID https://orcid.org/0000-0002-9140-9543
Shree R SinghCenter for NanoBiotechnology Research (CNBR), Department of Biological Sciences, Alabama State University, 1627 Harris Way, Montgomery, AL 36104, USA.
Vida A DennisCenter for NanoBiotechnology Research (CNBR), Department of Biological Sciences, Alabama State University, 1627 Harris Way, Montgomery, AL 36104, USA.ORCID https://orcid.org/0000-0003-1409-5605
Alabama State University · US

Funding

RISE Option II:NIGMS-Research Initiative for Scientific Enhancement (RISE) Program at ASUR25GM106995 · NIGMS · ALABAMA STATE UNIVERSITY · PI DENNIS, VIDA A · 2013 to 2023
$3.0M
Mechanisms and protective efficacy of nanovaccines against Chlamydia trachomatisR21AI111159 · NIAID · ALABAMA STATE UNIVERSITY · PI DENNIS, VIDA A · 2014 to 2015
$341k
NIAID NIH HHS R21 AI111159NIGMS NIH HHS R25 GM106995
6 · The paper itself

Abstract

The immunopathology of chlamydial diseases is exacerbated by a broad-spectrum of inflammatory mediators, which we reported are inhibited by IL-10 in macrophages. However, the chlamydial protein moiety that induces the inflammatory mediators and the mechanisms by which IL-10 inhibits them are unknown. We hypothesized that

Indexed as

AnimalsBacterial Outer Membrane ProteinsCell LineChlamydia muridarumFlow CytometryInflammationInterleukin-10MacrophagesMiceMicroscopy, FluorescenceSuppressor of Cytokine Signaling 1 ProteinSuppressor of Cytokine Signaling 3 ProteinBacterial Outer Membrane ProteinsInterleukin-10Socs1 protein, mouseSocs3 protein, mouseSuppressor of Cytokine Signaling 1 ProteinSuppressor of Cytokine Signaling 3 Protein

Identifiers

PMID32684836
PMCPMC7333066
OpenAlexW3037836525

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.