Evidence map›Paper›PMID 32684823›Full record

ReviewReproductive medicine and biology2020

Endocrine-disrupting chemicals and male reproductive health.

Aditi Sharma, Josephine Mollier, Richard W K Brocklesby, Charlotte Caves, Channa N Jayasena, Suks Minhas

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Reproductive medicine and biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07703046 (Endocrine Disruptors and Men's Reproductive Health), which is not on this map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
7.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07703046 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Endocrine Disruptors and Men's Reproductive Health: A Randomized Behavioral Intervention to Increase Environmental Health Literacy and Reduce Exposures Among Men With Low Semen Quality

TypeinterventionalSponsorMillion Marker Wellness, Inc.Ran2026 to 2027Enrolled100ConditionsFertility, Male Fertility, Sperm Count, Low, Sperm QualityArmsEDC Education Intervention
3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 135 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Endocrine Disruption and Male Fertility.Current environmental health reports · 2026
    Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Aditi SharmaSection of Investigative Medicine Faculty of Medicine Imperial College London London UK.ORCID https://orcid.org/0000-0002-3198-0879
Josephine MollierSection of Investigative Medicine Faculty of Medicine Imperial College London London UK.
Richard W K BrocklesbySection of Investigative Medicine Faculty of Medicine Imperial College London London UK.
Charlotte CavesSection of Investigative Medicine Faculty of Medicine Imperial College London London UK.
Channa N JayasenaSection of Investigative Medicine Faculty of Medicine Imperial College London London UK.
Suks MinhasImperial Centre for Andrology Imperial College Healthcare NHS Trust London UK.
Imperial College London · GBImperial College Healthcare NHS Trust · GB

Funding

Department of Health PDF-2017-10-098
6 · The paper itself

Abstract

backgroundA number of different types of endocrine-disrupting chemicals (EDCs) including bisphenol A, phthalates, pesticides, and other environmental chemicals have been shown to adversely impact upon male reproductive health. Understanding the potential effects of EDCs on male reproductive health may enable the development of novel treatments and early prevention of the effects of EDCs on male infertility and their potential long-term sequelae. This review critically evaluates the research performed in this area and explores potential harmful effects of EDCs in animals and humans, including the possibility of trans-generational transmission.

methodsA literature review was conducted using electronic databases using the following terms: 'endocrine disrupt*' OR 'endocrine disruptors' OR 'endocrine disruptor chemicals' OR 'EDC' AND 'sperm*' OR 'spermatozoa' OR 'spermatozoon' OR 'male reproductive health' OR' male fertility'. MAIN

findingsSeveral studies have shown that EDCs have a variety of pathophysiological effects. These include failure of spermatogenesis, embryonic development, the association with testicular cancer, and long-term metabolic effects.

conclusionsSeveral studies observe correlations between chemical doses and at least one sperm parameter; however, such correlations are sometimes inconsistent between different studies. Mechanisms through which EDCs exert their pathophysiological effects have not yet been fully elucidated in human studies.

Indexed as

endocrine‐disrupting chemicalsenvironmentalmale infertilitysemen qualitysperm

Identifiers

PMID32684823
PMCPMC7360961
OpenAlexW3016625010

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.