Evidence map›Paper›PMID 32684794›Full record

ArticleTropical medicine and health2020

Pathogen genomic surveillance of typhoidal

Carl D Britto, Sitarah Mathias, Ashish Bosco, Zoe A Dyson, Gordon Dougan, Savitha Raveendran, V L Abin, Sanju Jose, Savitha Nagaraj, Kathryn E Holt and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tropical medicine and health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 4 countries.

Carl D BrittoOxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, OX3 7LE UK.ORCID 0000-0002-1674-8801
Sitarah MathiasSt. John's Medical College Hospital and Division of Infectious Disease, St. John's Research Institute, Bangalore, India.
Ashish BoscoSt. John's Medical College Hospital and Division of Infectious Disease, St. John's Research Institute, Bangalore, India.
Zoe A DysonDepartment of Infectious Diseases, Central Clinical School, Monash University, Melbourne, Victoria 3004 Australia.
Gordon DouganDepartment of Medicine, University of Cambridge, Cambridge, UK.
Savitha RaveendranDepartment of Infectious Diseases, Central Clinical School, Monash University, Melbourne, Victoria 3004 Australia.
V L AbinDepartment of Infectious Diseases, Central Clinical School, Monash University, Melbourne, Victoria 3004 Australia.
Sanju JoseDepartment of Infectious Diseases, Central Clinical School, Monash University, Melbourne, Victoria 3004 Australia.
Savitha NagarajDepartment of Infectious Diseases, Central Clinical School, Monash University, Melbourne, Victoria 3004 Australia.
Kathryn E HoltDepartment of Infectious Diseases, Central Clinical School, Monash University, Melbourne, Victoria 3004 Australia.
Andrew J PollardOxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, OX3 7LE UK.
Monash University · AUSt.John's Medical College Hospital · INUniversity of London · GBSt. John's University · USUniversity of Cambridge · GBUniversity of Oxford · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

backgroundIndia is endemic for enteric fever, and it is not known whether the variations in clinical manifestations between patients are due to host, environmental or pathogen factors.Blood culture surveillance was conducted at St. John's Medical College Hospital, Bangalore, between July 2016 and June 2017. Clinical, laboratory and demographic data were collected from each case, and bacterial isolates were subjected to whole genome sequencing. Comparative analysis between adults and paediatric patients was carried out to ascertain differences between adult and paediatric disease.

resultsAmong the 113 cases of blood culture-confirmed enteric fever, young adults (16-30 years) and children < 15 years accounted for 47% and 37% of cases, respectively. Anaemia on presentation was seen in 46% of cases, and 19% had an abnormal leucocyte count on presentation. The majority received treatment as inpatients (70%), and among these, adults had a significantly longer duration of admission when compared with children (

conclusionsAmidst the many public health concerns of South India, enteric fever continues to contribute substantially to hospital burden with non-specific as well as uncommon clinical features in both paediatric and adult populations likely driven by host and environmental factors. Robust clinical surveillance as well monitoring of pathogen population structure is required to inform treatment and preventive strategies.

Indexed as

Clinical featuresEnteric feverH58IndiaParatyphiTyphi

Identifiers

PMID32684794
PMCPMC7359007
OpenAlexW3041839385

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.