ArticleWorld journal of gastroenterology2020
Consensus on the definition of colorectal anastomotic leakage: A modified Delphi study.
Article in World journal of gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 7 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Radiotherapy as a potential risk factor for delayed anastomotic leakage after rectal surgery: a meta-analysis.BMC surgery · 2025Pooled it
- Risk prediction models for permanence of temporary stoma after radical surgery of rectal cancer: a systematic review.World journal of surgical oncology · 2025Pooled it
- Impact of Anastomotic Leakage After Colorectal Cancer Surgery on Quality of Life: A Systematic Review.Diseases of the colon and rectum · 2025Pooled it
- Indocyanine Green Fluorescence Imaging for Colorectal Surgery: A Health Technology Assessment.Ontario health technology assessment series · 2025Pooled it
- Association of computed tomography-derived body composition and complications after colorectal cancer surgery: A systematic review and meta-analysis.Journal of cachexia, sarcopenia and muscle · 2024Pooled it
- Effect of transanal drainage tube on prevention of anastomotic leakage after anterior rectal cancer surgery taking indwelling time into consideration: a systematic review and meta-analysis.Frontiers in oncology · 2023Pooled it
- Enhancing intestinal anastomotic healing using butyrate: Systematic review and meta-analysis of experimental animal studies.PloS one · 2023Pooled it
- Impact of safe-anastomosis digital training on 30-day anastomotic leak after right colectomy: international prospective cohort study (EAGLE-2).The British journal of surgery · 2026Article
- Prevention, Recognition, and Management of Anastomotic Leakage and Pelvic Sepsis After Rectal Cancer Surgery: A Structured Narrative Review.Journal of clinical medicine · 2026Review
- Standardization of international diverticular disease definitions.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026Article
- Emergency Surgery and the Risk of Anastomotic Leakage After Colorectal Resection with Primary Anastomosis for Benign and Malignant Disease: A Single-Center Retrospective Study.Journal of clinical medicine · 2026Article
- Review
- Costs associated with anastomotic leak after left-sided colorectal surgery: retrospective real-world study in England.BJS open · 2026Article
- Anastomotic leakage in colorectal cancer surgery in Syria: risk factors and improvements following guideline implementation - a retrospective cohort study.Annals of medicine and surgery (2012) · 2026Article
- A single-center retrospective study of prophylactic loop ileostomies and transverse end colostomies after laparoscopic radical resection for rectal cancer: a comparison of safety and functional outcomes.International journal of colorectal disease · 2026Observational
- Anastomotic Leak Following Colorectal Surgery.Clinics in colon and rectal surgery · 2026Review
- Mesenteric excision and Kono-S anastomosis trial (MEErKAT): A study protocol for a multicentre, 2 × 2 factorial, randomised controlled, open-label superiority trial.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025Article
- Prior antibiotics exposure is associated with an elevated risk of surgical site infections, including anastomotic leakage, after colon cancer but not rectal cancer surgery: A register-based study of 38,839 patients.International journal of cancer · 2025Article
- Article
- What Is the Role of the Gut Microbiota in Anastomotic Leakage After Colorectal Resection? A Scoping Review of Clinical and Experimental Studies.Journal of clinical medicine · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite the emerging knowledge about colorectal anastomotic leakage (CAL) through the increasing number of clinical and experimental studies, there is no generally accepted definition of CAL. Because of the wide variety of definitions used in literature, comparison of study outcomes and quality of care is complicated.
aimTo reach consensus on the definition of CAL using a modified Delphi method.
methodsThe RAND/UCLA appropriateness method was used. The expert panel consisted of international colorectal surgeons and researchers who had published three or more articles about CAL. The consensus process consisted of two online distributed questionnaires and a third round with a recommendation. In the questionnaires participants were asked to rate the appropriateness of statements using a 1-9 Likert scale. Consensus was defined as a panel median between 1-3 or 7-9 without disagreement. In the final round a recommendation was formed regarding the definition of CAL and the expert panel was asked if they agreed or disagreed.
resultsTwenty-three authors participated in the first round and twenty-one finished the second round. After two rounds consensus was reached on 37 items (80%) in nine different categories. The International Study Group of Rectal Cancer definition is the most frequently advised general definition by our panel. Consensus was reached regarding the clinical symptoms of CAL, which serum markers contributes to the suspicion of CAL, which radiological and perioperative findings should be considered as CAL, which grading system is appropriate and if there should be a range of postoperative days in the definition. Eventually, 19 experts completed all three rounds of which 16 (84%) agreed with our final recommendations for the definition of CAL.
conclusionA consensus-based recommendation for the definition of CAL was formed using our modified Delphi method that can be widely incorporated in the field.
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