Evidence map›Paper›PMID 32684739›Full record

ArticleWorld journal of gastroenterology2020

Medications in type-2 diabetics and their association with liver fibrosis.

Mohamed Tausif Siddiqui, Hina Amin, Rajat Garg, Pravallika Chadalavada, Wael Al-Yaman, Rocio Lopez, Amandeep Singh

Open access · hybridAbstract read
In one paragraph

Article in World journal of gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

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  6. The Influence of Hyperglycemia on Liver Triglyceride Deposition in Partially Pancreatectomized Rats.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mohamed Tausif SiddiquiDepartment of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute, Cleveland Clinic, Cleveland, OH 44195, United States.
Hina AminDepartment of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute, Cleveland Clinic, Cleveland, OH 44195, United States.
Rajat GargDepartment of Hospital Medicine, Cleveland Clinic, OH 44195, United States.
Pravallika ChadalavadaDepartment of Hospital Medicine, Cleveland Clinic, OH 44195, United States.
Wael Al-YamanDepartment of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute, Cleveland Clinic, Cleveland, OH 44195, United States.
Rocio LopezDepartment of Quantitative Health Sciences, Cleveland Clinic, OH 44195, United States.
Amandeep SinghDepartment of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute, Cleveland Clinic, Cleveland, OH 44195, United States. singha4@ccf.org.
Cleveland Clinic · US

Funding

Combined Training Program in Digestive Disease SciencesT32DK083251 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI COMINELLI, FABIO, FIOCCHI, CLAUDIO · 2010 to 2025
$3.6M
NIDDK NIH HHS T32 DK083251
6 · The paper itself

Abstract

backgroundThe prevalence of nonalcoholic fatty liver disease (NAFLD) is significantly rising worldwide. Type-2 diabetes (T2D) is a major risk factor for NAFLD progression.

aimTo assess the association of commonly used medications to advanced fibrosis (AF) in patients with biopsy-proven NAFLD and T2D.

methodsWe used the International Classification of Disease 9

resultsA total of 1183 patients were included in the final analysis, out of which 32% (

conclusionIn our cohort of T2D with biopsy proven NAFLD, the patients who were receiving metformin, liraglutide, lisinopril, hydrochlorothiazide, atorvastatin and simvastatin were less likely to have AF on biopsy, while patients who were receiving furosemide and spironolactone had a higher likelihood of having AF when they underwent liver biopsy. Future studies are needed to confirm these findings and to establish measures for prevention of NAFLD progression in patients with T2D.

Indexed as

Diabetes Mellitus, Type 2MetforminNon-alcoholic Fatty Liver DiseaseBiopsyFemaleHumansLiverLiver CirrhosisMaleMiddle AgedMetforminAdvanced fibrosisAntihypertensive medicationAnti-lipid medicationsDiabetes medicationsFatty liver

Identifiers

PMID32684739
PMCPMC7336333
OpenAlexW3036942177

What OpenQuestion holds

Texttitle and abstract
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.