Evidence map›Paper›PMID 32684557›Full record

Observational studyJournal of atherosclerosis and thrombosis2021

Atrial Septal Aneurysm may Cause In-Hospital Recurrence of Cryptogenic Stroke.

Ayako Kuriki, Yuji Ueno, Yuki Kamiya, Takahiro Shimizu, Ryosuke Doijiri, Yohei Tateishi, Muneaki Kikuno, Yoshiaki Shimada, Hidehiro Takekawa, Eriko Yamaguchi and 9 more

Open access · diamondAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of atherosclerosis and thrombosis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Atrial Septal Abnormalities and Cryptogenic Stroke: A Cross-Sectional Study.Cardiovascular & hematological disorders drug targets · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 9 institutions in 1 country.

Ayako KurikiDepartment of Neurology, Showa University Koto Toyosu Hospital.
Yuji UenoDepartment of Neurology, Juntendo University Faculty of Medicine.
Yuki KamiyaDepartment of Neurology, Showa University Koto Toyosu Hospital.
Takahiro ShimizuDepartment of Neurology, St.Marianna University School of Medicine.
Ryosuke DoijiriDepartment of Neurology, Iwate Prefectural Central Hospital.
Yohei TateishiDepartment of Neurology and Strokology, Nagasaki University Hospital.
Muneaki KikunoDepartment of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center.
Yoshiaki ShimadaDepartment of Neurology, Juntendo University Urayasu Hospital.
Hidehiro TakekawaDepartment of Neurology, Dokkyo Medical University.
Eriko YamaguchiDepartment of Neurology, Iwate Prefectural Central Hospital.
Masatoshi KogaDepartment of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center.
Masafumi IharaDepartment of Neurology, National Cerebral and Cardiovascular Center.
Kenjiro OnoDivision of Neurology, Department of Medicine, Showa University School of Medicine.
Akira TsujinoDepartment of Neurology and Strokology, Nagasaki University Hospital.
Koichi HirataDepartment of Neurology, Dokkyo Medical University.
Kazunori ToyodaDepartment of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center.
Yasuhiro HasegawaDepartment of Neurology, St.Marianna University School of Medicine.
Nobutaka HattoriDepartment of Neurology, Juntendo University Faculty of Medicine.
Takao UrabeDepartment of Neurology, Juntendo University Urayasu Hospital.
National Cerebral and Cardiovascular Center · JPDokkyo Medical University · JPIwate Prefectural Central Hospital · JPJuntendo University · JPJuntendo University Urayasu Hospital · JPNagasaki University Hospital · JPShowa University · JPSt. Marianna University School of Medicine · JPShowa University Koto Toyosu Hospital

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsAwareness of potentially embologenic diseases is critical to determining the prognosis of cryptogenic stroke. The clinical significance of atrial septal aneurysm (ASA) in cryptogenic stroke has not been fully studied. Therefore, we explored clinical characteristics and in-hospital recurrence in patients with ASA in cryptogenic stroke.

methodsA multicenter observational registry of cryptogenic stroke patients was conducted. We obtained baseline characteristics, radiological and laboratory findings, and echocardiographic findings, especially of embolic sources on transesophageal echocardiography. The CHALLENGE ESUS/CS (Mechanisms of Embolic Stroke Clarified by Transesophageal Echocardiography for embolic stroke of undetermined source/cryptogenic stroke) registry was recorded at http://www.umin.ac.jp/ctr/ (UMIN000032957). Patients' clinical characteristics were compared according to the presence of ASA, and factors associated with in-hospital stroke recurrence were assessed.

resultsThe study included 671 patients (age, 68.7±12.7 years; 450 males; median National Institutes of Health Stroke Scale score, 2). ASA was detected in 92 patients (14%), displaying higher age (72.4±11.0 vs. 68.1 ±12.9 years, p=0.004), reduced frequency of diabetes mellitus (16% vs. 27%, p=0.030), higher frequency of right-to-left shunt (66% vs. 45%, p＜0.001), and in-hospital stroke recurrence (8% vs. 3%, p=0.034). ASA was relatively associated with in-hospital recurrence (odds ratio 2.497, 95% confidence interval 0.959-6.500, p= 0.061).

conclusionsThe CHALLENGE ESUS/CS registry indicated that ASA was not rare in cryptogenic stroke, and ASA's clinical characteristics included higher age, reduced frequency of diabetes mellitus, and increased frequency of concomitant right-to-left shunt. ASA may be related to in-hospital stroke recurrence in cryptogenic stroke.

Indexed as

Atrial SeptumAgedAged, 80 and overEchocardiography, TransesophagealFemaleHeart AneurysmHospitalizationHumansIschemic StrokeJapanLogistic ModelsMagnetic Resonance ImagingMaleMiddle AgedOdds RatioRecurrenceAtrial septal aneurysmCryptogenic strokeStrokeTransesophageal echocardiography

Identifiers

PMID32684557
PMCPMC8193779
OpenAlexW3042468995

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.