Evidence map›Paper›PMID 32684498›Full record

ArticleVaccine2020

A listeriolysin O subunit vaccine is protective against Listeria monocytogenes.

Christopher C Phelps, Stephen Vadia, Prosper N Boyaka, Sanjay Varikuti, Zayed Attia, Purnima Dubey, Abhay R Satoskar, Rodney Tweten, Stephanie Seveau

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Listeria monocytogenes: from a saprophytic to a cytosolic virulent pathogen.World journal of microbiology & biotechnology · 2025
    Review
  7. Metabolic mechanisms of immunotherapy resistance.Exploration of targeted anti-tumor therapy · 2025
    Review
  8. Review
  9. Article
  10. Review
  11. Pathogens (Basel, Switzerland) · 2022
    Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Christopher C PhelpsDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA; Department of Microbiology, The Ohio State University, The Ohio State University, Columbus, OH, USA.
Stephen VadiaDepartment of Microbiology, The Ohio State University, The Ohio State University, Columbus, OH, USA; Department of Biology, Washington University in St. Louis, MO 63130, USA.
Prosper N BoyakaDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA; Department of Veterinary Biosciences, The Ohio State University, Columbus, OH, USA.
Sanjay VarikutiDepartment of Pathology, The Ohio State University, Columbus, OH, USA.
Zayed AttiaDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH, USA.
Purnima DubeyDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.
Abhay R SatoskarDepartment of Pathology, The Ohio State University, Columbus, OH, USA.
Rodney TwetenDepartment of Microbial & Immunology, University of Oklahoma, Oklahoma City, OK, USA.
Stephanie SeveauDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA; Department of Microbiology, The Ohio State University, The Ohio State University, Columbus, OH, USA. Electronic address: seveau.1@osu.edu.
The Ohio State University · USUniversity of Oklahoma · US

Funding

Pore Formation by Cholesterol Dependent CytolysinsR37AI037657 · NIAID · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI TWETEN, RODNEY K. · 2016 to 2025
$4.8M
Multifaceted activity of listeriolysin O during host cell invasion by ListeriaR01AI107250 · NIAID · OHIO STATE UNIVERSITY · PI SEVEAU, STEPHANIE M M · 2014 to 2018
$1.9M
NIAID NIH HHS R01 AI107250NIAID NIH HHS R37 AI037657
6 · The paper itself

Abstract

Listeria monocytogenes is a facultative intracellular pathogen responsible for the life-threatening disease listeriosis. The pore-forming toxin listeriolysin O (LLO) is a critical virulence factor that plays a major role in the L. monocytogenes intracellular lifecycle and is indispensable for pathogenesis. LLO is also a dominant antigen for T cells involved in sterilizing immunity and it was proposed that LLO acts as a T cell adjuvant. In this work, we generated a novel full-length LLO toxoid (LLO

Indexed as

Bacterial ToxinsListeria monocytogenesListeriosisAnimalsHeat-Shock ProteinsHemolysin ProteinsMiceVaccines, SubunitBacterial ToxinsHeat-Shock ProteinsHemolysin ProteinshlyA protein, Listeria monocytogenesVaccines, SubunitCancer immunotherapyCholesterol-dependent cytolysinListeria monocytogenesListeriolyin OVaccine

Identifiers

PMID32684498
PMCPMC7788512
OpenAlexW3043036727

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.