Evidence map›Paper›PMID 32684393›Full record

Observational studyThe Journal of thoracic and cardiovascular surgery2022

Gait speed is a preoperative indicator of postoperative events after elective proximal aortic surgery.

Reilly D Hobbs, Elizabeth L Norton, Xiaoting Wu, Cristen J Willer, Scott L Hummell, Richard L Prager, Jonathan Afilalo, Whitney E Hornsby, Bo Yang

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in The Journal of thoracic and cardiovascular surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. A Cross-Sectional Study on the Characteristics of Physical Activity in Pre-Frail Older Adults.International journal of environmental research and public health · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Reilly D HobbsUniversity of Michigan, Michigan Medicine, Ann Arbor, Mich; Department of Cardiac Surgery, Michigan Medicine, Ann Arbor, Mich.
Elizabeth L NortonCreighton University School of Medicine, Omaha, Neb.
Xiaoting WuUniversity of Michigan, Michigan Medicine, Ann Arbor, Mich; Department of Cardiac Surgery, Michigan Medicine, Ann Arbor, Mich.
Cristen J WillerUniversity of Michigan, Michigan Medicine, Ann Arbor, Mich; Department of Internal Medicine, Michigan Medicine, Ann Arbor, Mich; Department of Biostatistics, University of Michigan, School of Public Health, Ann Arbor, Mich; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Mich.
Scott L HummellUniversity of Michigan, Michigan Medicine, Ann Arbor, Mich; Department of Internal Medicine, Michigan Medicine, Ann Arbor, Mich.
Richard L PragerUniversity of Michigan, Michigan Medicine, Ann Arbor, Mich; Department of Cardiac Surgery, Michigan Medicine, Ann Arbor, Mich.
Jonathan AfilaloMcGill University - Jewish General Hospital, Montreal, Quebec, Canada; Division of Cardiology and Centre for Clinical Epidemiology, Jewish General Hospital, Montreal, Quebec, Canada.
Whitney E HornsbyUniversity of Michigan, Michigan Medicine, Ann Arbor, Mich; Department of Internal Medicine, Michigan Medicine, Ann Arbor, Mich. Electronic address: whornsby@med.umich.edu.
Bo YangUniversity of Michigan, Michigan Medicine, Ann Arbor, Mich; Department of Cardiac Surgery, Michigan Medicine, Ann Arbor, Mich. Electronic address: boya@med.umich.edu.
University of Michigan · USCreighton University · USJewish General Hospital · CAMichigan Medicine · US

Funding

Using genetics to discover mechanisms of myocardial infarctionR01HL109946 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YUQING Eugene CHEN, Ida Liisa Surakka · 2011 to 2026
$8.9M
Genetic Predisposition To Thoracic Aortic Aneurysms/DissectionsR01HL109942 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MILEWICZ, DIANNA M · 2012 to 2023
$7.5M
Using genetic variation to study biology of blood lipids & coronary heart diseaseR01HL127564 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Pradeep Natarajan, Gina Marie Peloso · 2015 to 2026
$7.3M
Using Genetics to Inform Mechanism of Cardiovascular DiseaseR35HL135824 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WILLER, CRISTEN J · 2017 to 2022
$5.4M
Define the mechanisms of aortopathy in bicuspid aortic valve patientsR01HL141891 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YANG, BO · 2018 to 2022
$3.5M
Integrative analysis to uncover biology of blood lipids & coronary heart diseaseR01HL142023 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WILLER, CRISTEN J, ZHOU, XIANG · 2018 to 2019
$859k
Effect of mutations in the TGF-beta pathway genes on smooth muscle cell differentiation using patient derived iPSCs.K08HL130614 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YANG, BO · 2016 to 2020
$848k
NHLBI NIH HHS K08 HL130614NHLBI NIH HHS R01 HL109942NHLBI NIH HHS R01 HL109946NHLBI NIH HHS R01 HL127564NHLBI NIH HHS R01 HL141891NHLBI NIH HHS R01 HL142023NHLBI NIH HHS R35 HL135824
6 · The paper itself

Abstract

objectiveThe study objective was to evaluate whether 5-m gait speed, an established marker of frailty, is associated with postoperative events after elective proximal aortic surgery.

methodsWe performed a retrospective review of 435 patients aged more than 60 years who underwent elective proximal aortic surgery, defined as surgery on the aortic root, ascending aorta, or aortic arch through median sternotomy. Patients completed a 5-m gait speed test within 30 days before surgery. We evaluated the association between categoric (slow, ≤0.83 m/s and normal, >0.83 m/s) and continuous gait speed and the likelihood of experiencing the composite outcome before and after adjustment for European System for Cardiac Operative Risk Evaluation II. The composite outcome included in-hospital mortality, renal failure, prolonged ventilation, and discharge location. Secondary outcomes were 1-year mortality and 5-year survival.

resultsOf the study population, 30.3% (132/435) were categorized as slow. Slow walkers were significantly more likely to have in-hospital mortality, prolonged ventilation, and renal failure, and were less likely to be discharged home (all P < .05). The composite outcome was 2 times more likely to occur for slow walkers (gait speed categoric adjusted odds ratio, 2.08; 95% confidence interval, 1.27-3.40; P = .004). Moreover, a unit (1 m/s) increase in gait speed (continuous) was associated with 73% lower risk of experiencing the composite outcome (odds ratio, 0.27; 95% confidence interval, 0.11-0.68; P = .006).

conclusionsSlow gait speed is a preoperative indicator of risk for postoperative events after elective proximal aortic surgery. Gait speed may be an important tool to complement existing operative risk models, and its application may identify patients who may benefit from presurgical and postsurgical rehabilitation.

Indexed as

Mobility LimitationVascular Surgical ProceduresWalking SpeedAgedAortaElective Surgical ProceduresFemaleFrailtyFunctional StatusGeriatric AssessmentHospital MortalityHumansMaleMiddle AgedPatient DischargePostoperative Complicationsfrailtygait speedproximal aortic surgeryrisk analysis

Identifiers

PMID32684393
PMCPMC8722375
OpenAlexW3027884750

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.