Evidence map›Paper›PMID 32684121›Full record

ArticleJournal of feline medicine and surgery2021

Pilot study assessing the use of cabergoline for the treatment of cats with hypersomatotropism and diabetes mellitus.

Christopher J Scudder, Katarina Hazuchova, Ruth Gostelow, David B Church, Yaiza Forcada, Robert C Fowkes, Stijn Jm Niessen

Open access · greenAbstract read
In one paragraph

Article in Journal of feline medicine and surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Feline Comorbidities: Hypersomatotropism-induced diabetes in cats.Journal of feline medicine and surgery · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Christopher J ScudderComparative Biomedical Sciences, The Royal Veterinary College, Hatfield, UK.ORCID 0000-0002-9896-9893
Katarina HazuchovaClinical Science and Services, The Royal Veterinary College, Hatfield, UK.
Ruth GostelowClinical Science and Services, The Royal Veterinary College, Hatfield, UK.ORCID 0000-0001-9354-8291
David B ChurchClinical Science and Services, The Royal Veterinary College, Hatfield, UK.
Yaiza ForcadaClinical Science and Services, The Royal Veterinary College, Hatfield, UK.
Robert C FowkesComparative Biomedical Sciences, The Royal Veterinary College, Hatfield, UK.
Stijn Jm NiessenClinical Science and Services, The Royal Veterinary College, Hatfield, UK.
Royal Veterinary College · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesAn affordable and effective treatment is needed to manage feline hypersomatotropism. The aim of this study was to assess whether treatment with oral cabergoline for 90 days in cats with hypersomatotropism and diabetes mellitus improved diabetic and insulin-like growth factor 1 (IGF-1) control.

methodsThis was a prospective cohort non-blinded pilot study enrolling client-owned cats with spontaneously occurring diabetes mellitus and hypersomatotropism. Cats received oral cabergoline (5-10 µg/kg q24h) for 90 consecutive days. Serum IGF-1 and fructosamine concentrations were measured on days 1, 30 and 90. Quality of life was determined using the DIAQoL-pet questionnaire on days 1 and 90.

resultsNine cats were enrolled and eight completed the study. There was no significant change in the following: IGF-1 (day 1 median 2001 ng/ml [range 890-2001 ng/ml]; day 30 median 2001 ng/ml [range 929-2001 ng/ml]; day 90 median 1828 ng/ml [range 1035-2001 ng/ml]; χ CONCLUSIONS AND RELEVANCE: Cabergoline did not improve diabetic control or normalise insulin-like growth factor concentration, or improve patient quality of life.

Indexed as

AcromegalyCat DiseasesDiabetes MellitusAnimalsCabergolineCatsInsulin-Like Growth Factor IPilot ProjectsProspective StudiesQuality of LifeCabergolineInsulin-Like Growth Factor IAcromegalygrowth-hormoneIGF-1pituitary

Identifiers

PMID32684121
PMCPMC10741349
OpenAlexW3045425869

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.