ArticleJournal of psychopharmacology (Oxford, England)2021
Reduced risk for hospitalization due to hyponatraemia in lithium treated patients: A Swedish population-based case-control study.
Article in Journal of psychopharmacology (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 8 citations in OpenAlex.
- Validation of ICD-10 codes used to identify the main reason for hospitalization due to hyponatremia in Sweden.PloS one · 2025Article
- Association between lipid-lowering agents and severe hyponatremia: a population-based case-control study.European journal of clinical pharmacology · 2021Article
- Catatonia Associated with Hyponatremia: Case Report and Brief Review of the Literature.Clinical practice and epidemiology in mental health : CP & EMH · 2021Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany drugs used in psychiatry have been reported to cause hyponatraemia. However, lithium may be an exception due to its potential for causing nephrogenic diabetes insipidus, but clinical data are largely absent. The objective of this investigation was to study the association between lithium therapy and hospitalization due to hyponatraemia.
methodsThis study was a register-based case-control investigation of the general Swedish population. Patients hospitalized with a principal diagnosis of hyponatraemia (
resultsCompared with controls, the unadjusted odds ratio (OR) (95% confidence interval (CI)) for hospitalization due to hyponatraemia was 1.07 (0.70-1.59) for lithium. However, after adjustment for confounding factors the risk was reduced (adjusted OR: 0.53 (0.31-0.87)). Newly initiated lithium therapy was not significantly associated with hyponatraemia (adjusted OR 0.73 (0.35-5.38)). In contrast, for ongoing therapy the corresponding adjusted OR was significantly reduced (adjusted OR: 0.52 (0.30-0.87)).
conclusionsA marked inverse association was found between ongoing lithium therapy and hospitalization due to hyponatraemia.
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