Evidence map›Paper›PMID 32683950›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2020

Posttranscriptional regulation of thiamin transporter-1 expression by microRNA-200a-3p in pancreatic acinar cells.

Kalidas Ramamoorthy, Kasin Yadunandam Anandam, Tomoya Yasujima, Padmanabhan Srinivasan, Hamid M Said

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. miR-122-5p is involved in posttranscriptional regulation of the mitochondrial thiamin pyrophosphate transporter (American journal of physiology. Gastrointestinal and liver physiology · 2023
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Kalidas RamamoorthyDepartment of Physiology and Biophysics, School of Medicine, University of California, Irvine, California.
Kasin Yadunandam AnandamDepartment of Physiology and Biophysics, School of Medicine, University of California, Irvine, California.
Tomoya YasujimaDepartment of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Japan.
Padmanabhan SrinivasanDepartment of Physiology and Biophysics, School of Medicine, University of California, Irvine, California.
Hamid M SaidDepartment of Physiology and Biophysics, School of Medicine, University of California, Irvine, California.
Long Beach Medical Center · USNagoya City University · JPUniversity of California, Irvine · US

Funding

INTESTINAL VITAMIN H UPTAKE--MOLECULAR/CELL REGULATIONR01DK058057 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI SAID, HAMID M · 2000 to 2019
$6.8M
Physiology/Pathophysiology of Vitamin B1 Transport in Pancreatic Acinar CellsR01AA018071 · NIAAA · UNIVERSITY OF CALIFORNIA-IRVINE · PI SAID, HAMID M · 2009 to 2023
$6.3M
Vitamin B1 (thiamin) transport in Alzheimer’s Disease: Role of microRNAs in regulating level of expression of its transporters (SLC19A2 & SLC19A3) in human brain cells and effect of hypoxiaR01DK056061 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI SAID, HAMID M · 1999 to 2024
$5.0M
Mechanism/Regulation of Intestinal Thiamin UptakeR37DK056061 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI SAID, HAMID M · 2009 to 2018
$3.6M
Physiological and Pathological Aspects of Intestinal Vitamin B2 AbsorptionI01BX001142 · VA · VETERANS HEALTH ADMINISTRATION · PI HAMID M SAID · 2011 to 2026
–
BLRD VA I01 BX001142NIAAA NIH HHS R01 AA018071NIDDK NIH HHS R01 DK056061NIDDK NIH HHS R01 DK058057NIDDK NIH HHS R37 DK056061NIH HHS AA 018071NIH HHS DK56061NIH HHS DK58057U.S. Department of Veterans Affairs (VA) I01BX001142
6 · The paper itself

Abstract

The water-soluble vitamin B1 (thiamin) plays essential roles in normal metabolism and function of all human/mammalian cells, including the pancreatic acinar cells (PACs). PACs obtain thiamin from their surrounding circulation via transport across the plasma membrane, a process that is mediated by thiamin transporter (THTR)-1 and THTR-2. We have previously characterized different aspects of thiamin uptake by mouse and human primary PACs, but little is known about posttranscriptional regulation of the uptake event. We addressed this by focusing on the predominant thiamin transporter THTR-1 (encoded by

Indexed as

3' Untranslated RegionsAcinar CellsAnimalsHumansMembrane Transport ProteinsMiceMicroRNAsMutationPancreasPrimary Cell CultureRNA Processing, Post-TranscriptionalThiamine3' Untranslated RegionsMembrane Transport ProteinsMicroRNAsMIRN200 microRNA, humanSLC19A2 protein, humanSlc19a2 protein, mouseThiaminemicroRNApancreatic acinar cellsposttranscriptional regulationSLC19A2thiamin uptakeTHTR-1

Identifiers

PMID32683950
PMCPMC7509260
OpenAlexW3045192932

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.