ArticleJournal of the American Chemical Society2020
High-Resolution XFEL Structure of the Soluble Methane Monooxygenase Hydroxylase Complex with its Regulatory Component at Ambient Temperature in Two Oxidation States.
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Article in Journal of the American Chemical Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
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44 citing papers in PubMed, 68 citations in OpenAlex.
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- Tracking the redox reaction of the iron enzyme ribonucleotide reductase using continuous SerialED and SFX.Structure (London, England : 1993) · 2026Article
- Cryo-EM Structures Reveal the Molecular Basis of Asymmetric Allosteric Activation by MMOB in the Hydroxylase of Soluble Methane Monooxygenase.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Heme oxygenase-like dimetal oxidases and oxygenases.Biochemical Society transactions · 2026Review
- TheProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Structural basis of the promiscuity of the unusual Fe(II) and 2-oxoglutarate dependent human aspartate/asparagine-β-hydroxylase.Nature communications · 2026Article
- Unsymmetric bimetallic centres in metalloproteins and synthetic models.Nature reviews. Chemistry · 2026Review
- Sample delivery methods for protein X-ray crystallography with a special focus on sample consumption.Nature communications · 2025Review
- Harnessing the potential of microbial methane utilization for chasing sustainability.Current opinion in biotechnology · 2025Review
- Structural insights into full-length human fascin1: a target for cancer treatment.Acta crystallographica. Section F, Structural biology communications · 2025Article
- Robust error calibration for serial crystallography.Acta crystallographica. Section D, Structural biology · 2025Article
- Macromolecular crystallography and biology at the Linac Coherent Light Source.Journal of synchrotron radiation · 2025Article
- X-ray Absorption Spectroscopy of Dilute Metalloenzymes at X-ray Free-Electron Lasers in a Shot-by-Shot Mode.The journal of physical chemistry letters · 2025Article
- Direct Methane Oxidation by Copper- and Iron-Dependent Methane Monooxygenases.Chemical reviews · 2024Review
- Going around the Kok cycle of the water oxidation reaction with femtosecond X-ray crystallography.IUCrJ · 2023Article
- Room temperature X-ray absorption spectroscopy of metalloenzymes with drop-on-demand sample delivery at XFELs.Pure and applied chemistry. Chimie pure et appliquee · 2023Article
- Modular droplet injector for sample conservation providing new structural insight for the conformational heterogeneity in the disease-associated NQO1 enzyme.Lab on a chip · 2023Article
- Combining on-line spectroscopy with synchrotron and X-ray free electron laser crystallography.Current opinion in structural biology · 2023Review
Corrections and comments
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Authors and funding
36 authors at 9 institutions in 6 countries.
Vivek SrinivasDepartment of Biochemistry and Biophysics, Stockholm University, Arrhenius Laboratories for Natural Sciences, Stockholm 106 91, Sweden.ORCID 0000-0002-0265-1873
Rahul BanerjeeDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 55391, United States.ORCID 0000-0002-8193-7369
Hugo LebretteDepartment of Biochemistry and Biophysics, Stockholm University, Arrhenius Laboratories for Natural Sciences, Stockholm 106 91, Sweden.ORCID 0000-0002-8081-181X
Jason C JonesDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 55391, United States.ORCID 0000-0002-3924-2846
Oskar AureliusDepartment of Biochemistry and Biophysics, Stockholm University, Arrhenius Laboratories for Natural Sciences, Stockholm 106 91, Sweden.
In-Sik KimMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
Cindy C PhamMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
Sheraz GulMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.ORCID 0000-0001-8920-8737
Kyle D SutherlinMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
Asmit BhowmickMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.ORCID 0000-0002-6154-6635
Juliane JohnDepartment of Biochemistry and Biophysics, Stockholm University, Arrhenius Laboratories for Natural Sciences, Stockholm 106 91, Sweden.ORCID 0000-0001-9626-3670
Esra BozkurtDepartment of Biochemistry and Biophysics, Stockholm University, Arrhenius Laboratories for Natural Sciences, Stockholm 106 91, Sweden.ORCID 0000-0001-8492-1162
Thomas FranssonInterdisciplinary Center for Scientific Computing, University of Heidelberg, 69120 Heidelberg, Germany.
Pierre AllerDiamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE, United Kingdom.ORCID 0000-0002-1793-7030
Agata ButrynDiamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE, United Kingdom.ORCID 0000-0002-5227-4770
Isabel BogaczMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.ORCID 0000-0003-1493-3867
Philipp SimonMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.ORCID 0000-0002-2859-4475
Stephen KeableMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
Alexander BritzLCLS, SLAC National Accelerator Laboratory, Menlo Park, California 94025, United States.ORCID 0000-0002-1049-2841
Kensuke TonoJapan Synchrotron Radiation Research Institute, Sayo-gun 679 5198, Japan.
Kyung Sook KimPohang Accelerator Laboratory, Gyeongsangbuk-do 37673, South Korea.
Sang-Youn ParkPohang Accelerator Laboratory, Gyeongsangbuk-do 37673, South Korea.
Sang Jae LeePohang Accelerator Laboratory, Gyeongsangbuk-do 37673, South Korea.
Jaehyun ParkPohang Accelerator Laboratory, Gyeongsangbuk-do 37673, South Korea.ORCID 0000-0002-9007-4892
Roberto Alonso-MoriLCLS, SLAC National Accelerator Laboratory, Menlo Park, California 94025, United States.
Franklin D FullerLCLS, SLAC National Accelerator Laboratory, Menlo Park, California 94025, United States.
Alexander BatyukLCLS, SLAC National Accelerator Laboratory, Menlo Park, California 94025, United States.ORCID 0000-0002-9393-2880
Aaron S BrewsterMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
Uwe BergmannStanford PULSE Institute, SLAC National Accelerator Laboratory, Menlo Park, California 94025, United States.ORCID 0000-0001-5639-166X
Nicholas K SauterMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
Allen M OrvilleDiamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE, United Kingdom.ORCID 0000-0002-7803-1777
Vittal K YachandraMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.ORCID 0000-0002-3983-7858
Junko YanoMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.ORCID 0000-0001-6308-9071
John D LipscombDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 55391, United States.ORCID 0000-0002-8158-5594
Jan KernMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
Martin HögbomDepartment of Biochemistry and Biophysics, Stockholm University, Arrhenius Laboratories for Natural Sciences, Stockholm 106 91, Sweden.ORCID 0000-0001-5574-9383
Lawrence Berkeley National Laboratory · USStockholm University · SESLAC National Accelerator Laboratory · USPohang University of Science and Technology · KRUniversity of Minnesota · USDiamond Light Source · GBHeidelberg University · DEJapan Synchrotron Radiation Research Institute · JPRutherford Appleton Laboratory · GB
Funding
TRAINING FOR FUTURE BIOTECHNOLOGY DEVELOPMENTT32GM008347 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI SCHMIDT-DANNERT, CLAUDIA · 1990 to 2021
$11.0MTaking Snapshots of the Water-Oxidation Reaction by the Mn4Ca Oxygen-Evolving Complex Using X-ray Crystallography and SpectroscopyR01GM055302 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI YACHANDRA, VITTAL · 1997 to 2022
$9.1MDIALS: New Computational Methods to Enable Challenging Crystallographic ExperimentsR01GM117126 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI SAUTER, NICHOLAS K · 2016 to 2023
$6.1MBiological Spectroscopy and Crystallography Using an X-ray Free Electron Laser - Supplemental EquipmentR01GM110501 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Junko Yano · 2014 to 2026
$4.8MHigh throughput sample delivery method for time resolved studies of enzyme reactions with X-ray and complementary techniquesR01GM126289 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI KERN, JAN F · 2017 to 2025
$4.6MIntermediates in O2 Activation by Oxygenases at Non-heme Iron CentersR35GM118030 · NIGMS · UNIVERSITY OF MINNESOTA · PI LIPSCOMB, JOHN D · 2016 to 2020
$2.7MHigh-end X-ray Detector System for Femtosecond CrystallographyS10OD023453 · OD · STANFORD UNIVERSITY · PI BOUTET, SEBASTIEN · 2017 to 2017
$1.7MStructure and Function of the Mn Oxygen-Evolving ComplexR56GM055302 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI YACHANDRA, VITTAL · 2009 to 2009
$530kQuantum refinement for improvement of metalloenzyme crystal structuresF32GM133081 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI SUTHERLIN, KYLE D. · 2019 to 2019
$48kBiotechnology and Biological Sciences Research Council 102593NIGMS NIH HHS F32 GM133081NIGMS NIH HHS R01 GM055302NIGMS NIH HHS R01 GM110501NIGMS NIH HHS R01 GM117126NIGMS NIH HHS R01 GM126289NIGMS NIH HHS R35 GM118030NIGMS NIH HHS R56 GM055302NIGMS NIH HHS T32 GM008347NIH HHS S10 OD023453Wellcome TrustWellcome Trust 210734/Z/18/Z
Abstract
Soluble methane monooxygenase (sMMO) is a multicomponent metalloenzyme that catalyzes the conversion of methane to methanol at ambient temperature using a nonheme, oxygen-bridged dinuclear iron cluster in the active site. Structural changes in the hydroxylase component (sMMOH) containing the diiron cluster caused by complex formation with a regulatory component (MMOB) and by iron reduction are important for the regulation of O
Indexed as
TemperatureMethylosinus trichosporiumModels, MolecularOxidation-ReductionOxygenasesSolubilityX-Raysmethane monooxygenaseOxygenases
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