ArticleCurrent microbiology2020
Leptospira interrogans Retains Direct Virulence After Long Starvation in Water.
Article in Current microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Longitudinal Survey of Pathogenic Leptospira Species at a Major Park in Sydney, Australia.EcoHealth · 2026Article
- Molecular Detection and Genotyping of PathogenicMicroorganisms · 2026Article
- Genotyping Reveals Potential Sources of Human Leptospirosis Outbreaks in Aotearoa New Zealand.Zoonoses and public health · 2026Article
- Review
- Whole Genome Characterization ofPathogens (Basel, Switzerland) · 2025Article
- Case-control study of leptospirosis in Aotearoa New Zealand reveals behavioural, occupational, and environmental risk factors.Epidemiology and infection · 2025Article
- Are PathogenicTropical medicine and infectious disease · 2024Article
- Pathogenic Leptospira contamination in the environment: a systematic review.Infection ecology & epidemiology · 2024Review
- Leptospirosis and the Environment: A Review and Future Directions.Pathogens (Basel, Switzerland) · 2023Review
- Degradation of p0071 and p120-catenin during adherens junction disassembly byFrontiers in cellular and infection microbiology · 2023Article
- Determining the spatial distribution of environmental and socio-economic suitability for human leptospirosis in the face of limited epidemiological data.Infectious diseases of poverty · 2022Article
- Article
- Analysis of human clinical and environmental Leptospira to elucidate the eco-epidemiology of leptospirosis in Yaeyama, subtropical Japan.PLoS neglected tropical diseases · 2022Article
- Heterologous production of the adhesin LIC13411 from pathogenicFrontiers in cellular and infection microbiology · 2022Article
- Identification of pathogenic Leptospira species and serovars in New Zealand using metabarcoding.PloS one · 2021Article
- Article
- Time series models for prediction of leptospirosis in different climate zones in Sri Lanka.PloS one · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Mostly studied as a zoonosis, leptospirosis is also an environment-borne infection and most human cases originate from soil or water contaminations. Yet, only few studies have been interested in the survival of pathogenic Leptospira in freshwater. In this study, water microcosms were designed to evaluate the survival and virulence of Leptospira spp. for 2 years. Four commercial bottled drinking waters and a non-ionized water, all previously filter-sterilized, were studied. Either one of two Leptospira interrogans strains, one Leptospira borgpetersenii strain, or a saprophytic Leptospira biflexa was inoculated in these waters under nutrient-deprived conditions. Molecular, microscopic and cultural approaches were used to study Leptospira survival. Direct virulence of the pathogens was assessed using animal challenge without re-culturing. Our results confirmed the capacity of pathogenic Leptospira to survive for more than a year in water. In addition, we showed the ability of L. interrogans in nutrient-deprived conditions to directly cause systemic infection in susceptible animals. To our knowledge, this is the first report of direct infection of a susceptible host with Leptospira following a long starvation and survival period in nutrient-deprived water. Our results also suggest that Leptospira turned into a physiological "survival" state in harsh freshwater conditions. These data are of prime importance considering that freshwater is a major source of Leptospira infections. Environmental survival and virulence of pathogenic Leptospira spp. are becoming a crucial challenge to determine the environmental risk and adopt relevant prevention and control strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.