Evidence map›Paper›PMID 32682872›Full record

ReviewProgress in neuro-psychopharmacology & biological psychiatry2021

Advances in novel molecular targets for antidepressants.

Qingzhong Wang, Yogesh Dwivedi

Open access · greenAbstract readReview
In one paragraph

Review in Progress in neuro-psychopharmacology & biological psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Qingzhong WangShanghai Key Laboratory of Compound Chinese Medicines, The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yogesh DwivediDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: ydwivedi@uab.edu.
Shanghai University of Traditional Chinese Medicine · CNUniversity of Alabama at Birmingham · US

Funding

Plasma Exosomal MicroRNAs as Promising Novel Biomarkers for Suicidality and Treatment OutcomeR01MH107183 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DWIVEDI, YOGESH, SHELTON, RICHARD CHARLES · 2015 to 2019
$3.5M
MicroRNA Mapping in Major DepressionR01MH100616 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DWIVEDI, YOGESH · 2014 to 2019
$1.8M
Perturbed cell signaling network and suicide neurobiologyR01MH101890 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DWIVEDI, YOGESH · 2013 to 2017
$1.6M
Calcium Sensing Proteins in DepressionR01MH082802 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DWIVEDI, YOGESH · 2009 to 2013
$1.4M
Validating microRNA Analysis in Human Postmortem BrainR21MH081099 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DWIVEDI, YOGESH · 2007 to 2008
$384k
NIMH NIH HHS R01 MH082802NIMH NIH HHS R01 MH100616NIMH NIH HHS R01 MH101890NIMH NIH HHS R01 MH107183NIMH NIH HHS R21 MH081099
6 · The paper itself

Abstract

Depression is the most common psychiatric illness affecting numerous people world-wide. The currently available antidepressant treatment presents low response and remission rates. Thus, new effective antidepressants need to be developed or discovered. Aiming to give an overview of novel possible antidepressant drug targets, we summarized the molecular targets of antidepressants and the underlying neurobiology of depression. We have also addressed the multidimensional perspectives on the progress in the psychopharmacological treatment of depression and on the new potential approaches with effective drug discovery.

Indexed as

Antidepressive AgentsBrainDepressive DisorderDrug Discoverygamma-Aminobutyric AcidGlutamic AcidHumansAntidepressive Agentsgamma-Aminobutyric AcidGlutamic AcidAntidepressantAnxiolyticsDepressionNovel targets

Identifiers

PMID32682872
PMCPMC7484229
OpenAlexW3043338032

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.