ArticleReproductive toxicology (Elmsford, N.Y.)2020
Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies.
Article in Reproductive toxicology (Elmsford, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Systematic transcriptome-wide meta-analysis across endocrine disrupting chemicals reveals shared and unique liver pathways, gene networks, and disease associations.Environment international · 2024Pooled it
- The assumption of a threshold is false in risk assessments for endocrine disrupting chemicals (EDCs) when endogenous hormones being disrupted are already above any possible threshold: a policy failure by the US FDA.Environmental health : a global access science source · 2026Review
- Developmental basis of male nipple loss and retention in mammals.Research square · 2025Article
- Serotonergic and Cholinergic Imbalance in the Offspring of Rats Exposed to Bisphenol A and Bisphenol S During Pregnancy and Lactation: Short- and Long-Term Effects.International journal of molecular sciences · 2025Article
- Carnosic Acid Attenuated the Motor Impairment by Bisphenol A is Related to the Regulation of Autophagy Through Parkin in In Vitro and In Vivo.Molecular neurobiology · 2025Article
- Determining a NOAEL for the consortium linking academic and regulatory insights on BPA toxicity (CLARITY-BPA) core study.Frontiers in toxicology · 2025Article
- Evaluating associations of bisphenol and phthalate exposure with time to pregnancy and subfecundity in a New York City pregnancy cohort.Environmental pollution (Barking, Essex : 1987) · 2024Article
- Should Pregnant Women Consume Probiotics to Combat Endocrine-Disrupting Chemical-Induced Health Risks to Their Unborn Offspring?Biomedicines · 2024Review
- The Conflict between Regulatory Agencies over the 20,000-Fold Lowering of the Tolerable Daily Intake (TDI) for Bisphenol A (BPA) by the European Food Safety Authority (EFSA).Environmental health perspectives · 2024Article
- Invited Perspective: Closing the Loop of Nonmonotonicity-from Natural Hormones in Experimental Endocrinology to Endocrine Disruptors in Epidemiology.Environmental health perspectives · 2024Article
- European Medicines Agency Conflicts With the European Food Safety Authority (EFSA) on Bisphenol A Regulation.Journal of the Endocrine Society · 2023Article
- Effects of perinatal exposure to bisphenol A on induction of prostate cancer in Sprague Dawley rats by MNU and testosterone.Toxicology · 2023Article
- Matrix Composition Modulates Vitamin D3's Effects on 3D Collagen Fiber Organization by MCF10A Cells.Tissue engineering. Part A · 2021Article
- Scientific discrepancies in European regulatory proposals on endocrine disruptors-REACH regulation quo vadis?Archives of toxicology · 2021Article
- REPRODUCTIVE TOXICOLOGY: Environmental exposures, fetal testis development and function: phthalates and beyond.Reproduction (Cambridge, England) · 2021Review
- The effects of plasticizers on the ovary.Current opinion in endocrine and metabolic research · 2021Article
- Elucidation of the Effects of Bisphenol A and Structural Analogs on Germ and Steroidogenic Cells Using Single Cell High-Content Imaging.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- From Wingspread to CLARITY: a personal trajectory.Nature reviews. Endocrinology · 2021Review
- Update on the Health Effects of Bisphenol A: Overwhelming Evidence of Harm.Endocrinology · 2021Review
- From Evidence of Harm to Public Health Policy: Is There Light at the End of the Tunnel? Response to: "Update on the Health Effects of bisphenol A: Overwhelming Evidence of Harm".Endocrinology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 9 institutions in 1 country.
Funding
Abstract
"Consortium Linking Academic and Regulatory Insights on BPA Toxicity" (CLARITY-BPA) was a comprehensive "industry-standard" Good Laboratory Practice (GLP)-compliant 2-year chronic exposure study of bisphenol A (BPA) toxicity that was supplemented by hypothesis-driven independent investigator-initiated studies. The investigator-initiated studies were focused on integrating disease-associated, molecular, and physiological endpoints previously found by academic scientists into an industry standard guideline-compliant toxicity study. Thus, the goal of this collaboration was to provide a more comprehensive dataset upon which to base safety standards and to determine whether industry-standard tests are as sensitive and predictive as molecular and disease-associated endpoints. The goal of this report is to integrate the findings from the investigator-initiated studies into a comprehensive overview of the observed impacts of BPA across the multiple organs and systems analyzed. For each organ system, we provide the rationale for the study, an overview of methodology, and summarize major findings. We then compare the results of the CLARITY-BPA studies across organ systems with the results of previous peer-reviewed studies from independent labs. Finally, we discuss potential influences that contributed to differences between studies. Developmental exposure to BPA can lead to adverse effects in multiple organs systems, including the brain, prostate gland, urinary tract, ovary, mammary gland, and heart. As published previously, many effects were at the lowest dose tested, 2.5μg/kg /day, and many of the responses were non-monotonic. Because the low dose of BPA affected endpoints in the same animals across organs evaluated in different labs, we conclude that these are biologically - and toxicologically - relevant.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.