Evidence map›Paper›PMID 32682565›Full record

SynthesisBiological psychiatry2021

Meta-analysis of the Glial Marker TSPO in Psychosis Revisited: Reconciling Inconclusive Findings of Patient-Control Differences.

Pontus Plavén-Sigray, Granville J Matheson, Jennifer M Coughlin, Sina Hafizi, Heikki Laurikainen, Julie Ottoy, Livia De Picker, Pablo Rusjan, Jarmo Hietala, Oliver D Howes and 4 more

Abstract readLetterMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Biological psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Microglia as critical mediators linking perinatal immune stress to mental health trajectories.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Pontus Plavén-SigrayCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden; Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Granville J MathesonCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
Jennifer M CoughlinDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Sina HafiziDepartment of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Heikki LaurikainenMolecular Imaging Center Antwerp, University of Antwerp, Antwerp, Belgium.
Julie OttoyMolecular Imaging Center Antwerp, University of Antwerp, Antwerp, Belgium.
Livia De PickerCollaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Antwerp, Belgium.
Pablo RusjanDepartment of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Jarmo HietalaDepartment of Psychiatry, University of Turku and Neuropsychiatric Imaging Group, Turku PET Centre, Turku University Hospital, Turku, Finland.
Oliver D HowesInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; MRC London Institute of Medical Sciences, Hammersmith Hospital, London, United Kingdom; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, United Kingdom.
Romina MizrahiDepartment of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Manuel MorrensCollaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Antwerp, Belgium.
Martin G PomperDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Simon CervenkaCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden. Electronic address: simon.cervenka@ki.se.

Funding

Training/Dissemination-Resource for Molecular Imaging Agents in Precision MedicineP41EB024495 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI MARTIN G POMPER · 2017 to 2026
$11.8M
Molecular imaging of brain injury and repair in NFL playersR01NS100847 · NINDS · JOHNS HOPKINS UNIVERSITY · PI COUGHLIN, JENNIFER MARIE · 2018 to 2023
$2.7M
Imaging Neuroinflammation in Clinical high risk and SchizophreniaR01MH100043 · NIMH · CENTRE FOR ADDICTION AND MENTAL HEALTH · PI MIZRAHI, ROMINA · 2014 to 2018
$1.6M
NIBIB NIH HHS P41 EB024495NIMH NIH HHS R01 MH100043NINDS NIH HHS R01 NS100847Wellcome Trust
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Psychotic DisordersHumansNeurogliaPositron-Emission TomographyReceptors, GABAReceptors, GABATSPO protein, human

Identifiers

PMID32682565
PMCPMC7899168

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.