Evidence map›Paper›PMID 32682290›Full record

ReviewCurrent opinion in immunology2020

Deciphering flavivirus-host interactions using quantitative proteomics.

Minghua Li, Holly Ramage, Sara Cherry

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Functional Roles and Host Interactions ofPathogens (Basel, Switzerland) · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Minghua LiDepartment of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Holly RamageDepartment of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: hramage@pennmedicine.upenn.edu.
Sara CherryDepartment of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: cherrys@pennmedicine.upenn.edu.
University of Pennsylvania · US

Funding

Training in Emerging Infectious DiseasesT32AI055400 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CHERRY, SARA, HENSLEY, SCOTT ERIC · 2003 to 2022
$4.4M
The role of pattern recognition and autophagy in innate anti-bunyaviral immunityR01AI150246 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CHERRY, SARA · 2019 to 2023
$3.5M
Defining the functional interface between the ER and flavivirusesR01AI140539 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CHERRY, SARA, DIAMOND, MICHAEL S · 2018 to 2022
$3.0M
Defining the Role of West Nile Virus-Host Protein Interactions in Evading Antiviral ImmunityR01AI143850 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI RAMAGE, HOLLY · 2019 to 2023
$2.2M
Defining the role of microbiota-derived cyclic dinucleotides in priming antiviral immune defenses.R01AI152362 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CHERRY, SARA · 2020 to 2024
$2.0M
Antiviral immunity in the gut: how the intestinal epithelium and microbiota regulate infectionR01AI122749 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CHERRY, SARA · 2016 to 2020
$2.0M
Elucidating the functional roles of long noncoding RNAs in Chikungunya virus infectionR21AI151882 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CHERRY, SARA · 2020 to 2021
$446k
NIAID NIH HHS R01 AI122749NIAID NIH HHS R01 AI140539NIAID NIH HHS R01 AI143850NIAID NIH HHS R01 AI150246NIAID NIH HHS R01 AI152362NIAID NIH HHS R21 AI151882NIAID NIH HHS T32 AI055400
6 · The paper itself

Abstract

Flaviviruses are a group of important emerging and re-emerging human pathogens that cause worldwide epidemics with thousands of deaths annually. Flaviviruses are small, enveloped, positive-sense, single-stranded RNA viruses that are obligate intracellular pathogens, relying heavily on host cell machinery for productive replication. Proteomic approaches have become an increasingly powerful tool to investigate the mechanisms by which viruses interact with host proteins and manipulate cellular processes to promote infection. Here, we review recent advances in employing quantitative proteomics techniques to improve our understanding of the complex interplay between flaviviruses and host cells. We describe new findings on our understanding of how flaviviruses impact protein-protein interactions, protein-RNA interactions, protein abundance, and post-translational modifications to modulate viral infection.

Indexed as

ProteomicsAnimalsFlavivirusHost-Pathogen InteractionsHumansProtein BindingProteinsVirus ReplicationProteins

Identifiers

PMID32682290
PMCPMC7749055
OpenAlexW3043789465

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.