ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2020
Waveform changes with the evolution of beta bursts in the human subthalamic nucleus.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Low-frequency activity in the subthalamic nucleus informs about the acute neuropsychiatric state in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Beyond beta rhythms: subthalamic aperiodic broadband power scales with Parkinson's disease severity-a cross-sectional multicentre study.EBioMedicine · 2025Article
- Neurophysiological gradient in the Parkinsonian subthalamic nucleus as a marker for motor symptoms and apathy.NPJ Parkinson's disease · 2025Article
- Quantifying Sharpness and Nonlinearity in Neonatal Seizure Dynamics.Cyborg and bionic systems (Washington, D.C.) · 2024Article
- Clinical neurophysiological interrogation of motor slowing: A critical step towards tuning adaptive deep brain stimulation.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Article
- The potential of convolutional neural networks for identifying neural states based on electrophysiological signals: experiments on synthetic and real patient data.Frontiers in human neuroscience · 2023Article
- Cross-Frequency Coupling and Intelligent Neuromodulation.Cyborg and bionic systems (Washington, D.C.) · 2023Review
- Balance between competing spectral states in subthalamic nucleus is linked to motor impairment in Parkinson's disease.Brain : a journal of neurology · 2022Article
- Within-cycle instantaneous frequency profiles report oscillatory waveform dynamics.Journal of neurophysiology · 2021Article
- An Impending Paradigm Shift in Motor Imagery Based Brain-Computer Interfaces.Frontiers in neuroscience · 2021Article
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Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
Abstract
objectivePhasic bursts of beta band synchronisation have been linked to motor impairment in Parkinson's disease (PD). However, little is known about what terminates bursts.
methodsWe used the Hilbert-Huang transform to investigate beta bursts in the local field potential recorded from the subthalamic nucleus in nine patients with PD on and off levodopa.
resultsThe sharpness of the beta waveform extrema fell as burst amplitude dropped. Conversely, an index of phase slips between waveform extrema, and the power of concurrent theta activity increased as burst amplitude fell. Theta activity was also increased on levodopa when beta bursts were attenuated. These phenomena were associated with reduction in coupling between beta phase and high gamma activity amplitude. We discuss how these findings may suggest that beta burst termination is associated with relative desynchronization of the beta drive, increase in competing theta activity and increased phase slips in the beta activity.
conclusionsWe characterise the dynamical nature of beta bursts, thereby permitting inferences about underlying activities and, in particular, about why bursts terminate. SIGNIFICANCE: Understanding the dynamical nature of beta bursts may help point to interventions that can cause their termination and potentially treat motor impairment in PD.
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