Evidence map›Paper›PMID 32681973›Full record

ReviewThe international journal of biochemistry & cell biology2020

Cardiac optical mapping - State-of-the-art and future challenges.

Christopher O'Shea, S Nashitha Kabir, Andrew P Holmes, Ming Lei, Larissa Fabritz, Kashif Rajpoot, Davor Pavlovic

Abstract readReview
In one paragraph

Review in The international journal of biochemistry & cell biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Article
  2. Review
  3. Fluorescence-lifetime optical electrophysiology in contracting cardiomyocytes.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Review
  5. Stretchable large-area transparent nanowire composite arrays for label-free multimodal interrogation of cardiac physiology.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Isolated Perfused Hearts for Cardiovascular Research: An Old Dog with New Tricks.Journal of cardiovascular translational research · 2024
    Review
  16. Optical mapping and optogenetics in cardiac electrophysiology research and therapy: a state-of-the-art review.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Review
  17. Article
  18. Virtual blebbistatin: A robust and rapid software approach to motion artifact removal in optical mapping of cardiomyocytes.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Christopher O'SheaInstitute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK.
S Nashitha KabirInstitute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK.
Andrew P HolmesInstitute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK; Institute of Clinical Sciences, University of Birmingham, Birmingham, UK.
Ming LeiDepartment of Pharmacology, University of Oxford, Oxford, UK.
Larissa FabritzInstitute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK; Department Cardiology, University Hospital Birmingham, Birmingham, UK.
Kashif RajpootSchool of Computer Science, University of Birmingham, Birmingham, UK.
Davor PavlovicInstitute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK. Electronic address: d.pavlovic@bham.ac.uk.

Funding

British Heart Foundation PG/17/30/32961British Heart Foundation PG/17/55/33087British Heart Foundation RG/17/15/33106Wellcome Trust 109604/Z/15/Z
6 · The paper itself

Abstract

Cardiac optical mapping utilises fluorescent dyes to directly image the electrical function of the heart at a high spatio-temporal resolution which far exceeds electrode techniques. It has therefore become an invaluable tool in cardiac electrophysiological research to map the propagation of heterogeneous electrical signals across the myocardium. In this review, we introduce the principles behind cardiac optical mapping and discuss some of the challenges and state of the art in the field. Key advancements discussed include newly developed fluorescent indicators, tools for the analysis of complex datasets, panoramic imaging systems and technical and computational approaches to realise optical mapping in freely beating hearts.

Indexed as

AnimalsHeartHumansOptical ImagingOptogeneticsAction potentialArrhythmiaCalcium transientCardiac optical mappingElectrophysiologyFluorescent imaging

Identifiers

PMID32681973
PMCPMC7456775

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.