ArticleClinica chimica acta; international journal of clinical chemistry2020
The diagnostic and prognostic role of myocardial injury biomarkers in hospitalized patients with COVID-19.
Article in Clinica chimica acta; international journal of clinical chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 8 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 8 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Prevalence of Cardiovascular Complications in Coronavirus Disease 2019 adult Patients: A Systematic Review and Meta-Analysis.Iranian journal of medical sciences · 2023Pooled it
- Effects of the pre-existing coronary heart disease on the prognosis of COVID-19 patients: A systematic review and meta-analysis.PloS one · 2023Pooled it
- Cardiac biomarkers and COVID-19: A systematic review and meta-analysis.Journal of infection and public health · 2021Pooled it
- Serum CK-MB, COVID-19 severity and mortality: An updated systematic review and meta-analysis with meta-regression.Advances in medical sciences · 2021Pooled it
- A meta-analysis on the risk factors adjusted association between cardiovascular disease and COVID-19 severity.BMC public health · 2021Pooled it
- Coronary heart disease and COVID-19: A meta-analysis.Medicina clinica · 2021Pooled it
- Meta-analysis of cardiac markers for predictive factors on severity and mortality of COVID-19.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021Pooled it
- B-Type Natriuretic Peptide Concentrations, COVID-19 Severity, and Mortality: A Systematic Review and Meta-Analysis With Meta-Regression.Frontiers in cardiovascular medicine · 2021Pooled it
- Characterization of Coronary Artery Disease in Sepsis Survivors.Biomedicines · 2025Article
- COVID-19 and coronary artery disease; A systematic review and meta-analysis.New microbes and new infections · 2023Review
- COVID-19, Myocarditis and Pericarditis.Circulation research · 2023Review
- Normal high-sensitivity cardiac troponin for ruling-out inpatient mortality in acute COVID-19.PloS one · 2023Article
- Inflammatory and Cardiac Biomarkers in Relation with Post-Acute COVID-19 and Mortality: What We Know after Successive Pandemic Waves.Diagnostics (Basel, Switzerland) · 2022Article
- Subclinical myocardial injury, coagulopathy, and inflammation in COVID-19: A meta-analysis of 41,013 hospitalized patients.International journal of cardiology. Heart & vasculature · 2022Article
- Hospitalized patients with breakthrough COVID-19: Clinical features and poor outcome predictors.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022Article
- Early carbohydrate antigen 125 as a mortality predictor in hospitalized patients with coronavirus disease 2019.Frontiers in cardiovascular medicine · 2022Article
- Bilirubin levels as an independent predictor of myocarditis in patients with COVID-19.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2021Article
- A simple prognostic score based on troponin and presepsin for COVID-19 patients admitted to the emergency department: a single-center pilot study.Acta bio-medica : Atenei Parmensis · 2021Article
- High-value laboratory testing for hospitalized COVID-19 patients: a review.Future virology · 2021Review
- Cardiac biomarkers in patients with COVID-19: pragmatic tools in hard times.Revista espanola de cardiologia (English ed.) · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to systematically and comprehensively evaluate the diagnostic and prognostic value of myocardial injury biomarkers in COVID-19 patients.
methodsThis is a retrospective cohort study of confirmed COVID-19 patients that were admitted to the Renmin Hospital of Wuhan University from January 30, 2020 to February 15, 2020.
resultsReceiver operating characteristic (ROC) curve analysis demonstrated that cTnI-ultra had the highest area under the curve (AUC) at 0.855, with a sensitivity of 67.3% and a specificity of 88.7% for the prediction of in-hospital mortality. Patients with higher troponin I-ultra (cTnI-ultra), creatinine kinase-myocardial band (CK-MB), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) were associated with higher mortality, compared to those who lower levels. The multivariable cox regression indicated that age (hazard ratio (HR) 3.450, 95% confidence interval (CI) 1.627-7.314, P = 0.001), coronary heart disease (HR 1.855, 95% CI 1.006-3.421; P = 0.048), elevated cTnI-ultra (HR 3.083, 95% CI 1.616-5.883, P = 0.001), elevated CK-MB (HR 2.907, 95% CI 1.233-6.854; P = 0.015), and elevated NT-proBNP (HR 5.776, 95% CI 2.272-14.682; P < 0.001) were associated with in-hospital mortality.
conclusionscTnI-ultra might be the best predictor of in-hospital mortality among myocardial injury biomarkers. Elevated cTnI-ultra, CK-MB, and NT-proBNP were independent biomarkers of the mortality in COVID-19 patients.
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