Evidence map›Paper›PMID 32681915›Full record

ArticleUrology2020

Sacral Nerve Stimulation in Parkinson's Disease Patients With Overactive Bladder Symptoms.

Daniel R Greenberg, Ericka M Sohlberg, Chiyuan A Zhang, Veronica E Santini, Craig V Comiter, Ekene A Enemchukwu

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Article in Urology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  5. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Daniel R GreenbergStanford University School of Medicine, Department of Urology, Stanford, CA. Electronic address: dgreenberg@stanford.edu.
Ericka M SohlbergStanford University School of Medicine, Department of Urology, Stanford, CA.
Chiyuan A ZhangStanford University School of Medicine, Department of Urology, Stanford, CA.
Veronica E SantiniStanford University School of Medicine, Department of Neurology and Neurological Sciences, Stanford, CA.
Craig V ComiterStanford University School of Medicine, Department of Urology, Stanford, CA.
Ekene A EnemchukwuStanford University School of Medicine, Department of Urology, Stanford, CA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess the efficacy, safety, and outcomes of sacral nerve stimulation (SNS) for Parkinson's disease (PD) patients with overactive bladder symptoms.

methodsWe retrospectively reviewed PD patients who underwent Stage I SNS. Demographics, urodynamic data, and baseline voiding function were analyzed. Efficacy and safety of treatment were determined by rate of progression to Stage II, explantation, and surgical revision. Long-term outcomes were assessed using voiding diaries and/or clinic notes.

resultsSixty percent (9/15) experienced ≥50% improvement in urinary parameters and proceeded to Stage II. There was no significant difference in age, body mass index, comorbidities, PD disease duration, or levodopa equivalent daily dose between successful and nonsuccessful Stage I patients. However, 100% of female patients experienced Stage I success compared to 44% of male PD patients (P = .04). Individuals with >12-month follow-up experienced an average reduction of 6 voids/day. No patients required revision or explantation of their device at latest clinic follow-up (22.2 ± 7.8 months). Higher maximal urethral closure pressures, detrusor pressure at maximum flow rate (PdetQmax), post-void residual volume, and mean bladder outlet obstruction index were observed in the Stage I trial failures.

conclusionAt our institution, PD patients have a similar rate of progression to Stage II compared to the general population. SNS is an effective therapy that should be considered among the treatment options for PD patients with overactive bladder symptoms. Urodynamic parameters associated with obstruction may be predictive of SNS failure in PD patients and may help guide patient selection, however further studies are needed.

Indexed as

AgedElectric Stimulation TherapyElectrodes, ImplantedFemaleHumansLumbosacral PlexusMaleParkinson DiseaseRetrospective StudiesSeverity of Illness IndexSex FactorsTreatment OutcomeUrinary BladderUrinary Bladder, Overactive

Identifiers

PMID32681915

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.