Evidence map›Paper›PMID 32681910›Full record

ArticleAmerican journal of ophthalmology2020

Differences in Clinical Features of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Optic Neuritis in White and Asian Race.

Tanyatuth Padungkiatsagul, John J Chen, Panitha Jindahra, Tetsuya Akaishi, Toshiyuki Takahashi, Ichiro Nakashima, Takayuki Takeshita, Heather E Moss

Open access · greenAbstract readComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Tanyatuth PadungkiatsagulDepartment of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Department of Ophthalmology, Stanford University, Palo Alto, California, USA.
John J ChenDepartment of Ophthalmology and Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Panitha JindahraDepartment of Neurology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Department of Ophthalmology and Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Tetsuya AkaishiDepartment of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Toshiyuki TakahashiDepartment of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Neurology, National Hospital Organization Yonezawa National Hospital, Yonezawa, Japan.
Ichiro NakashimaDepartment of Neurology, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Takayuki TakeshitaDepartment of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Heather E MossDepartment of Ophthalmology, Stanford University, Palo Alto, California, USA; Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, California, USA. Electronic address: hemoss@stanford.edu.
Tohoku University · JPMayo Clinic · USMahidol University · THPalo Alto University · USTohoku Medical and Pharmaceutical University · JP

Funding

Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2017 to 2026
$8.0M
NEI NIH HHS P30 EY026877
6 · The paper itself

Abstract

purposeTo determine whether clinical features and visual outcomes of myelin oligodendrocyte glycoprotein antibody-associated optic neuritis (MOG-ON) differ between White and Asian subjects.

designMulticenter retrospective cohort.

methodsThis was a multicenter study of 153 subjects who were White or Asian with a history of adult-onset (age 18 years or older) optic neuritis (ON) and positive MOG-IgG serology by cell-based assay. Subjects were enrolled from 2 unpublished cohorts (January 2017-November 2019) and 9 published cohorts with case-level data available (2012-2018). Subjects with alternative etiologies of demyelinating disease and positive or lack of aquaporin-4-IgG serology result were excluded. The main outcome measurements were clinical features and final visual outcomes.

resultsOf the 153 subjects who were White (n = 80) or Asian (n = 73) included in the study, 93 (61%) were women, mean age of onset was 40.8 ± 14.9 years, and median follow-up was 35.2 months (range: 1-432 months); all of these characteristics were similar between White and Asian subjects. White subjects were more likely to have recurrent ON (57 [71%] vs 20 [27%]; P = .001) and extra-optic nerve manifestations (35 [44%] vs 8 [11%]; P = .001). Optic disc swelling, neuroimaging findings, presenting visual acuity (VA), treatment, and final VA did not differ according to subjects' race. Despite the high prevalence of severe visual loss (<20/200) during nadir, most subjects had good recovery of VA (>20/40) at final examination (51/77 [66%] White subjects vs 52/70 [74%] Asian subjects).

conclusionWhite subjects with MOG-ON were more likely to have recurrent disease and extra-optic nerve manifestations. Visual outcomes were similar between White and Asian subjects.

Indexed as

AdultAquaporin 4Asian PeopleAutoantibodiesEye PainFemaleHumansImmunoglobulin GMaleMiddle AgedMyelin-Oligodendrocyte GlycoproteinOptic NeuritisRecurrenceRetrospective StudiesSlit Lamp MicroscopyThailandAQP4 protein, humanAquaporin 4AutoantibodiesImmunoglobulin GMOG protein, humanMyelin-Oligodendrocyte Glycoprotein

Identifiers

PMID32681910
PMCPMC7713508
OpenAlexW3042575377

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.