Evidence map›Paper›PMID 32681643›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2021

Disease Prevention Not Decolonization: A Model for Fecal Microbiota Transplantation in Patients Colonized With Multidrug-resistant Organisms.

Rohma Ghani, Benjamin H Mullish, Julie A K McDonald, Anan Ghazy, Horace R T Williams, Eimear T Brannigan, Siddharth Mookerjee, Giovanni Satta, Mark Gilchrist, Neill Duncan and 6 more

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06355583 (Intestinal Microbiota Transplant Prior to Allogeneic Stem Cell Transplant), which is not on this map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
1.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06355583 phase2recruitingnot on this mapstarted 2024, after this paper: background citation

Intestinal Microbiota Transplant Prior to Allogeneic Stem Cell Transplant (MAST) Trial

TypeinterventionalSponsorImperial College LondonRan2024 to 2027Enrolled50ConditionsAcute Lymphoblastic Leukaemia, Acute Leukemia of Ambiguous Lineage, Chronic Myeloid Leukemia, Chronic Myelomonocytic LeukemiaArmsEBX-102, Placebo
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 76 citations in OpenAlex.

  1. Trial
  2. Randomized Double-Blind Phase II Trial of Fecal Microbiota Transplantation Versus Placebo in Allogeneic Hematopoietic Cell Transplantation and AML.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023
    Trial
  3. Trial
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Antimicrobial Resistance: The Answers.British journal of biomedical science · 2026
    Review
  10. Article
  11. Review
  12. Microbiota and kidney disease: the road ahead.Nature reviews. Nephrology · 2025
    Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. IntestinalBMJ open · 2024
    Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Rohma GhaniDivision of Digestive Diseases, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, United Kingdom.
Benjamin H MullishDivision of Digestive Diseases, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, United Kingdom.
Julie A K McDonaldDivision of Digestive Diseases, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, United Kingdom.
Anan GhazyDepartment of Infection, Imperial College Healthcare NHS Trust, London, United Kingdom.
Horace R T WilliamsDivision of Digestive Diseases, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, United Kingdom.
Eimear T BranniganDepartment of Infection, Imperial College Healthcare NHS Trust, London, United Kingdom.
Siddharth MookerjeeDepartment of Infection, Imperial College Healthcare NHS Trust, London, United Kingdom.
Giovanni SattaDepartment of Infection, Imperial College Healthcare NHS Trust, London, United Kingdom.
Mark GilchristDepartment of Infection, Imperial College Healthcare NHS Trust, London, United Kingdom.
Neill DuncanDepartment of Renal Medicine, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.
Richard CorbettDepartment of Renal Medicine, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.
Andrew J InnesCentre for Haematology, Imperial College London, and Hammersmith Hospital, Imperial College London NHS Trust, London, United Kingdom.
Jiří PavlůCentre for Haematology, Imperial College London, and Hammersmith Hospital, Imperial College London NHS Trust, London, United Kingdom.
Mark R ThurszDivision of Digestive Diseases, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, United Kingdom.
Frances DaviesDepartment of Infection, Imperial College Healthcare NHS Trust, London, United Kingdom.
Julian R MarchesiDivision of Digestive Diseases, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, United Kingdom.
Imperial College Healthcare NHS Trust · GBHammersmith Hospital · GBImperial College London · GB

Funding

Medical Research Council MR/P028225/1Medical Research Council MR/R000875/1Medical Research Council MR/T005254/1
6 · The paper itself

Abstract

Fecal microbiota transplantation (FMT) yields variable intestinal decolonization results for multidrug-resistant organisms (MDROs). This study showed significant reductions in antibiotic duration, bacteremia, and length of stay in 20 patients colonized/infected with MDRO receiving FMT (compared with pre-FMT history, and a matched group not receiving FMT), despite modest decolonization rates.

Indexed as

Fecal Microbiota TransplantationGastrointestinal MicrobiomeAnti-Bacterial AgentsDrug Resistance, Multiple, BacterialHumansIntestinesAnti-Bacterial Agentsallogeneic hematopoietic cell transplantationantimicrobial resistancefecal microbiota transplantgut microbiomemultidrug-resistant bacteria

Identifiers

PMID32681643
PMCPMC8075030
OpenAlexW3042755040

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.