ArticleBrain pathology (Zurich, Switzerland)2021
Congenital tumors of the central nervous system: an institutional review of 64 cases with emphasis on tumors with unique histologic and molecular characteristics.
Article in Brain pathology (Zurich, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Spontaneous complete regression of congenital brain tumors - a systematic literature review and case report.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Pooled it
- Primary Intracranial High Grade Congenital Glial Lesions (PIHGCL): A systematic review of case reports from 1985 to 2025.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Pooled it
- Outcomes of Congenital Brain Tumors: A Single-Center Experience in a Low- and Middle-Income Country.Brain tumor research and treatment · 2026Article
- Morphological and Molecular Characterization of Infant-Type Hemispheric Glioma.Neurosciences (Riyadh, Saudi Arabia) · 2026Article
- Long-term prognosis and treatment outcomes in infantile and neonatal brain tumors.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Paediatric cranial ultrasound: abnormalities of the brain in term neonates and young infants.Insights into imaging · 2025Article
- Exploring neonatal brain tumors: a narrative review about epidemiology, classification, and management.Annals of medicine and surgery (2012) · 2025Review
- Congenital extraventricular neurocytoma with atypical features in a 3-day-old neonate.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- When Hemorrhage Hides a Fetal Brain Tumor, Importance of Fetal Autopsy.Clinical case reports · 2024Article
- Approaches to supratentorial brain tumours in children.Neuroradiology · 2024Review
- The Role of Early and Delayed Surgery for Infants with Congenital Brain Tumors.Cancer research and treatment · 2024Article
- Imaging of supratentorial intraventricular masses in children:a pictorial review- part 1.Neuroradiology · 2024Review
- Central nervous system tumours in neonates: what should the neonatologist know?European journal of pediatrics · 2024Review
- Prognostic value of Ki-67 index in primary intracranial tumors of infants.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- Intracranial Tumors in the First Year of Life.Advances and technical standards in neurosurgery · 2023Article
- Fetal Brain Tumors, a Challenge in Prenatal Diagnosis, Counselling, and Therapy.Journal of clinical medicine · 2022Article
- Congenital medulloblastoma presented in the neonatal period.Autopsy & case reports · 2021Article
- Methylation profiling-based diagnosis of radiologically suspected congenital glioma.Brain tumor pathology · 2021Article
- A Signature of Nine lncRNA Methylated Genes Predicts Survival in Patients With Glioma.Frontiers in oncology · 2021Article
- Challenges in diagnostics and treatment of infant-type hemispheric gliomas.Neuro-oncology advancesArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Congenital brain tumors are rare accounting for 0.5%-1.9% of all pediatric brain tumors. While different criteria have been used to classify a tumor as congenital, those diagnosed prior to 6 months of age are considered to be "probably" congenital in origin. We performed an institutional review of all central nervous system (CNS) tumors (surgical and autopsy specimens from 1990 to 2019) in patients less than 6 months old. Sixty-four unique cases were identified, and these accounted for 2.0% of all CNS tumor specimens at our institution. The most common tumor types were high-grade gliomas, low-grade gliomas and medulloblastomas. Atypical teratoid rhabdoid tumors, choroid plexus tumors and germ cell tumors also accounted for a significant portion of the cohort. Seven tumors were diagnosed prenatally. The most common clinical presentation at diagnosis was increased head circumference. At the conclusion of the study, over half of the patients were alive including all patients with WHO grade I and II tumors. Ninety-two percent of cases were classifiable using the 2016 WHO system, and when available, molecular findings supported the histologic diagnoses. However, several gliomas had unusual histologic features and did not correspond to a well-defined entity. Molecular testing was essential for accurate classification of a subset of these tumors, and several high-grade gliomas exhibited fusions considered unique to infantile gliomas, including those involving the MET, ALK and NTRK genes. To our knowledge, this cohort represents the largest single-institution study of congenital CNS tumors and highlights many ways in which congenital CNS tumors are distinct from CNS tumors of older pediatric patients and adults.
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