ArticleJournal of clinical laboratory analysis2020
Diagnostic value of peripheral hematologic markers for coronavirus disease 2019 (COVID-19): A multicenter, cross-sectional study.
Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04515108 (Comparison of Hematological Parameters and Perinatal Outcomes in COVID-19 Pregnancies and Healthy Pregnancy Cohort), which is not on this map. Cited by 55 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Hematological Parameters and Perinatal Outcomes in COVID-19 Pregnancies and Healthy Pregnancy Cohort
Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Impact of Neutrophil-Lymphocyte Count Ratio in COVID-19: A Systematic Review and Meta-Analysis.Journal of intensive care medicine · 2022Pooled it
- The diagnostic and prognostic role of neutrophil-to-lymphocyte ratio in COVID-19: a systematic review and meta-analysis.Expert review of molecular diagnostics · 2021Pooled it
- Different Innate and Adaptive Immune Responses to SARS-CoV-2 Infection of Asymptomatic, Mild, and Severe Cases.Frontiers in immunology · 2020Trial
- Platelet-to-Lymphocyte Ratio-A Real or Fake Bridge Between Inflammation and Coagulation in COVID-19 Patients: A Scoping Review.Diagnostics (Basel, Switzerland) · 2026Review
- Biochemical Markers as Predictors of Coronavirus Disease-2019 Severity and Intensive Care Unit Admission: A Retrospective Study in Saudi Arabia.Annals of African medicine · 2026Observational
- Predicting the timing of LC after PTGBD in elderly patients with acute cholecystitis: a machine learning approach with a web-based calculator.Langenbeck's archives of surgery · 2025Article
- Some Predictive Indexes Are Potentially Promising Clinical Parameters in Dogs with Primary Cholangitis-Cholangiohepatitis.Veterinary medicine and science · 2025Article
- Joint association of weight-adjusted waist index and serum cotinine levels with systemic inflammatory index in adults.BMC public health · 2025Article
- Inflammatory, Hematological, and Biochemical Biomarkers in COVID-19 Patients.Immunity, inflammation and disease · 2024Article
- Article
- Predictive modeling of COVID-19 mortality risk in chronic kidney disease patients using multiple machine learning algorithms.Scientific reports · 2024Article
- Non-Conventional Prognostic Markers in Life-Threatening COVID-19 Cases-When Less Is More.Journal of clinical medicine · 2024Article
- The Role of Different Systemic Inflammatory Indexes Derived from Complete Blood Count in Differentiating Acute from Chronic Calculus Cholecystitis and Predicting Its Severity.Journal of inflammation research · 2024Article
- Article
- Hematological, inflammatory, and novel biomarkers assessment as an eminent strategy for clinical management of COVID-19.Heliyon · 2023Article
- Increased risk of poor clinical outcome in COVID-19 patients with diabetes mellitus and in-hospital mortality predictors: A retrospective cohort from a tertiary hospital in Indonesia.Endocrinology, diabetes & metabolism · 2023Article
- Article
- Relationship between sarcopenia and cachexia with prognostic markers of middle-aged and older inpatients with COVID-19: a case-control study.European geriatric medicine · 2023Article
- The effect of diabetes mellitus on COVID-19 mortality among patients in a tertiary-level hospital in Bandung, Indonesia.PloS one · 2023Article
- Predictive Role of Biomarkers in COVID-19 Mortality.Cureus · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundTo determine the diagnostic value of hematologic markers for coronavirus disease 2019 (COVID-19) and explore their relationship with disease severity.
methodsSubjects included 190 COVID-19 patients, 190 healthy subjects, and 105 influenza pneumonia (IP) patients. COVID-19 patients were divided into the ARDS and non-ARDS groups. Routine blood examination, biochemistry indicator, days in hospital, body temperature, pneumonia severity index (PSI), CURB-65, and MuLBSTA were recorded. Correlations between variables were assessed using Spearman's correlation analysis. Receiver operating characteristic (ROC) curves were used to study the accuracy of the various diagnostic tests.
resultsCompared with healthy subjects, COVID-19 patients had lower white blood cell (WBC), lymphocyte, platelet, and hemoglobin levels; higher percentages of neutrophils and monocytes; lower percentages of lymphocytes and higher neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) values (P < .05). COVID-19 patients had higher WBC and neutrophil levels and lower percentages of lymphocytes compared to IP (P < .05). ROC curve analysis revealed that MLR had a high diagnostic value in differentiating COVID-19 patients from healthy subjects, but not from IP patients. NLR showed significant positive correlations with PSI, CURB-65, and MuLBSTA. Lymphocyte count was lower in the ARDS group and yielded a higher diagnostic value than the other variables.
conclusionsMonocyte-to-lymphocyte ratio showed an acceptable efficiency to separate COVID-19 patients from healthy subjects, but failed to rule out IP patients. NLR may be a reliable marker to evaluate the disease severity of COVID-19. Lymphocyte count may be useful to establish the early diagnosis of ARDS in the COVID-19 patients.
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