ReviewWorld journal of microbiology & biotechnology2020
Degeneration of industrial bacteria caused by genetic instability.
Review in World journal of microbiology & biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Meta-analysis Driven Strain Design for Mitigating Oxidative Stresses Important in Biomanufacturing.ACS synthetic biology · 2024Pooled it
- Transposon-based genome editing of industrial microorganisms: advances, challenges, and prospects.Synthetic and systems biotechnology · 2026Review
- Optimization of spinosad production by Saccharopolysosa spinosa YJY-12 and its application in controlling Eggplant Thrips.Scientific reports · 2025Article
- Isolation, Genomic Taxonomy, and Genome Characterization of Streptomyces fradiae SS162, Which has Antibacterial Activity Against Vibrio parahaemolyticus.Current microbiology · 2025Article
- Review
- Ochratoxin A Degradation and Stress Response Mechanism ofFoods (Basel, Switzerland) · 2024Article
- Promising non-model microbial cell factories obtained by genome reduction.Frontiers in bioengineering and biotechnology · 2024Review
- Enhancement of paclitaxel production by Neopestalotiopsis vitis via optimization of growth conditions.PloS one · 2024Article
- Creating Single-Cell Protein-ProducingScientifica · 2024Article
- Hyper-Production of Pullulan by a Novel Fungus ofInternational journal of molecular sciences · 2023Article
- New insights into phenotypic heterogeneity for the distinct lipid accumulation of Schizochytrium sp. H016.Biotechnology for biofuels and bioproducts · 2022Article
- Xylanase production by Thermobacillus xylanilyticus is impaired by population diversification but can be mitigated based on the management of cheating behavior.Microbial cell factories · 2022Article
- Construction of an IS-FreeFrontiers in bioengineering and biotechnology · 2021Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The fermentation of industrial bacteria encounters a serious problem in continuous culture, i.e. the production traits lose. However, current research on the mechanism of strain degeneration is not clear enough, and there are few methods to effectively control the degeneration. Under growth restriction, the mutation rate of fermentation strains increases. Many cellular processes and poor fermentation conditions can trigger the transposition of transposable elements, SOS response, and RpoS-controlled adaptive mutations, causing genetic instability. Genetic instability which resulted from point mutations and genomic rearrangements can be responsible for strain degeneration. This mini-review summarizes the degeneration phenomena and mechanisms in common industrial bacteria and highlights three mechanisms of strain degeneration, including the transposition of transposable elements, SOS response, and adaptive mutations. According to different mutation mechanisms, many promising strategies have been proposed to increase the stability and the yield of industrial strains, for example, developing platform strains free of insertion sequence to enhance the stability of recombinant plasmid, using SOS inhibitors to block the SOS response, and improving environmental tolerance capacity and fermentation conditions to reduce adaptive mutations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.