Evidence map›Paper›PMID 32681273›Full record

ArticleWorld journal of urology2021

Prospective assessment of two-gene urinary test with multiparametric magnetic resonance imaging of the prostate for men undergoing primary prostate biopsy.

Gian Maria Busetto, Francesco Del Giudice, Martina Maggi, Ferdinando De Marco, Angelo Porreca, Isabella Sperduti, Fabio Massimo Magliocca, Stefano Salciccia, Benjamin I Chung, Ettore De Berardinis and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 4 pooled it
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Gian Maria BusettoDepartment of Urology, Sapienza Rome University, Policlinico Umberto I, Viale del Policlinico 155, 00161, Rome, Italy.
Francesco Del GiudiceDepartment of Urology, Sapienza Rome University, Policlinico Umberto I, Viale del Policlinico 155, 00161, Rome, Italy.
Martina MaggiDepartment of Urology, Sapienza Rome University, Policlinico Umberto I, Viale del Policlinico 155, 00161, Rome, Italy. martina.maggi@uniroma1.it.
Ferdinando De MarcoI.N.I Istituto Neurotraumatologico Italiano-Urology Division-Grottaferrata, Grottaferrata, Rome, Italy.
Angelo PorrecaDepartment of Urology, Policlinico Abano Terme, Abano Terme, Italy.
Isabella SperdutiBiostatistical Unit-IRCCS, Regina Elena National Cancer Institute, Rome, Italy.
Fabio Massimo MaglioccaDepartment of Radiological, Oncological and Anatomopathological Sciences, Sapienza Rome University, Policlinico Umberto I, Rome, Italy.
Stefano SalcicciaDepartment of Urology, Sapienza Rome University, Policlinico Umberto I, Viale del Policlinico 155, 00161, Rome, Italy.
Benjamin I ChungDepartment of Urology, Stanford University Medical Center, Stanford, CA, USA.
Ettore De BerardinisDepartment of Urology, Sapienza Rome University, Policlinico Umberto I, Viale del Policlinico 155, 00161, Rome, Italy.
Alessandro SciarraDepartment of Urology, Sapienza Rome University, Policlinico Umberto I, Viale del Policlinico 155, 00161, Rome, Italy.
Policlinico Umberto I · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITPoliclinico Abano Terme · ITStanford Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the diagnostic accuracy of SelectMDx and its association with multiparametric magnetic resonance (mpMRI) in predicting prostate cancer (PCa) and clinically significant PCa (csPCa) on prostate biopsies among men scheduled for initial prostate biopsy.

methodsIn this single-center prospective study, 52 men scheduled for initial prostate biopsy, based on elevated total PSA level (> 3 ng/ml) or abnormal digital rectal examination, were consecutively included. All subjects underwent SelectMDx, PSA determination and mpMRI.

resultsSelectMDx score was positive in 94.1 and 100% of PCa and csPCa, respectively, and in only 8.6% of negative cases at biopsy. The probability for a csPCa at the SelectMDx score was significantly (p = 0.002) higher in csPCa (median value 52.0%) than in all PCa (median value 30.0%). SelectMDx showed slightly lower sensitivity (94.1 versus 100.0%) but higher specificity (91.4%) than total PSA (17.1%), and the same sensitivity but higher specificity than mpMRI (80.0%) in predicting PCa at biopsy. The association of SelectMDx plus mpMRI rather than PSA density (PSAD) plus mpMRI showed higher specificity (both 91.4%) compared to the association of PSA plus mpMRI (85.7%). In terms of csPCa predictive value, SelectMDx showed higher specificity (73.3%) than PSA (13.3%) and mpMRI (64.4%); as for the association of SelectMDx plus mpMRI (75.6%) versus PSA plus mpMRI (68.9%), the association of PSAD plus mpMRI showed the highest specificity (80.0%).

conclusionOur results of SelectMDx can be confirmed as significant but their impact on clinical practice together with a cost-effectiveness evaluation should be investigated in a larger prospective multicenter analysis.

Indexed as

Multiparametric Magnetic Resonance ImagingAdultAgedBiomarkers, TumorCell Cycle ProteinsHomeodomain ProteinsHumansImage-Guided BiopsyMaleMiddle AgedProspective StudiesProstateProstatic NeoplasmsReproducibility of ResultsTranscription FactorsBiomarkers, TumorCell Cycle ProteinsDistal-less homeobox proteinsHomeodomain ProteinsHOXC6 protein, humanTDRD1 protein, humanTranscription FactorsmpMRIProstate biopsyProstate neoplasmPSAUrinary biomarker

Identifiers

PMID32681273
PMCPMC8217060
OpenAlexW3042883190

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.