ArticleIrish journal of medical science2021
Lipid reference values in an Irish population.
Article in Irish journal of medical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Age- and sex-specific reference values for plasma lipids and lipoproteins in thai adults: a national health examination survey analysis.Journal of health, population, and nutrition · 2025Article
- Serum Lipoprotein Profiling by NMR Spectroscopy Reveals Alterations in HDL-1 and HDL-2 Apo-A2 Subfractions in Alzheimer's Disease.International journal of molecular sciences · 2024Article
- The LDL cumulative exposure hypothesis: evidence and practical applications.Nature reviews. Cardiology · 2024Review
- Assessing Performance of Martins's and Sampson's Formulae for Calculation of LDL-C in Indian Population: A Single Center Retrospective Study.Indian journal of clinical biochemistry : IJCB · 2024Article
- Reference intervals for cardiometabolic risk factors in China: a national multicenter cross-sectional study on an adult population sample.Cardiovascular diagnosis and therapy · 2024Article
- The Impact of Abnormal Lipid Metabolism on the Occurrence Risk of Idiopathic Pulmonary Arterial Hypertension.International journal of molecular sciences · 2023Article
- Lipid Levels During Adult Lifetime in Men and Women With and Without a Subsequent Incident Myocardial Infarction: A Longitudinal Analysis of Data From the Tromsø Study 1974 to 2016.Journal of the American Heart Association · 2023Article
- Associations of maternal metabolic profile with placental and fetal cerebral and cardiac hemodynamics.European journal of obstetrics, gynecology, and reproductive biology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsThere is limited information on reference values for lipids and lipoproteins in an Irish population. In this observational study, we have described the distributions of lipids in a large Irish cohort.
methodsOver 110,000 lipid profiles were selected from a database of almost 1.5 million consecutive lipid profiles performed in the Clinical Biochemistry Laboratory in University Hospital Galway between 2004 and 2017 to best represent the Irish population. Age- and sex-related reference intervals for both sexes for total cholesterol, triglycerides, HDL cholesterol and LDL cholesterol, from the age of ten to greater than 90 years, were determined. Two methods for estimating LDL cholesterol were also compared.
resultsSex-related differences in lipid distributions arise before the age of 20 years and are life-long. In both sexes total and LDL cholesterol levels gradually increased towards middle age with a decrease towards old age. Levels tended to be higher in males than in females up to mid-life at which stage they cross over with females having on average higher levels. The median of the triglyceride distributions show similar age- and sex-related changes to total cholesterol, but the distributions show a very marked positive skew that is particularly obvious in middle aged males. HDL cholesterol distributions change little throughout life with males having lower levels than females. Changing from the Friedewald formula to that proposed by Martin would impact the management of some patients with dyslipidaemia.
conclusionsThis study provides lipid reference values for clinical biochemistry laboratories and clinicians working in Ireland. It is informative for public health initiatives wishing to target dyslipidaemia as a modifiable risk for cardiovascular disease and for investigators researching geographical and temporal variances in lipid parameters.
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