Evidence map›Paper›PMID 32681257›Full record

ArticleCurrent medical science2020

Yu Gan Long Ameliorates Hepatic Fibrosis by Inhibiting PI3K/AKT, Ras/ERK and JAK1/STAT3 Signaling Pathways in CCl

Hou-Gang Li, Peng-Tao You, Yu Xia, Yu Cai, Yi-Jun Tu, Meng-Heng Wang, Wan-Ci Song, Tai-Min Quan, Hui-Ying Ren, Yan-Wen Liu and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Current medical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Major bioactive metabolites derived fromFrontiers in pharmacology · 2026
    Review
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  7. [Tofacitinib inhibits the transformation of lung fibroblasts into myofibroblasts through JAK/STAT3 pathway].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2024
    Article
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Hou-Gang Li *Hubei Key Laboratory of Resources and Chemistry of Chinese Medicine, Hubei University of Chinese Medicine, Wuhan, 430065, China.
Peng-Tao You *Hubei Key Laboratory of Resources and Chemistry of Chinese Medicine, Hubei University of Chinese Medicine, Wuhan, 430065, China. tptyou@hbtcm.edu.cn.
Yu XiaHubei Key Laboratory of Resources and Chemistry of Chinese Medicine, Hubei University of Chinese Medicine, Wuhan, 430065, China.
Yu CaiCollege of Pharmacy, Hubei University of Chinese Medicine, Wuhan, 430065, China.
Yi-Jun TuHubei Key Laboratory of Resources and Chemistry of Chinese Medicine, Hubei University of Chinese Medicine, Wuhan, 430065, China.
Meng-Heng WangHubei Key Laboratory of Resources and Chemistry of Chinese Medicine, Hubei University of Chinese Medicine, Wuhan, 430065, China.
Wan-Ci SongCollege of Pharmacy, Hubei University of Chinese Medicine, Wuhan, 430065, China.
Tai-Min QuanCollege of Pharmacy, Hubei University of Chinese Medicine, Wuhan, 430065, China.
Hui-Ying RenCollege of Pharmacy, Hubei University of Chinese Medicine, Wuhan, 430065, China.
Yan-Wen LiuHubei Key Laboratory of Resources and Chemistry of Chinese Medicine, Hubei University of Chinese Medicine, Wuhan, 430065, China.
Han-Xiong DanHubei Key Laboratory of Resources and Chemistry of Chinese Medicine, Hubei University of Chinese Medicine, Wuhan, 430065, China.
Shi-Qing XuWuhan Junan Pharmaceutical Co., Ltd., Wuhan, 430023, China. 1035158535@qq.com.
Hubei University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Yu Gan Long (YGL) is a Chinese traditional herbal formula which has been reported to attenuate liver fibrosis for many years and we have explored its anti-fibrotic mechanism through blocking transforming growth factor (TGF-β) in the previous study. But the mechanisms associated with platelet-derived growth factor (PDGF)-BB remain obscure. In this study, we further investigated the mechanism of YGL reducing carbon tetrachloride (CCl

Indexed as

AnimalsCarbon TetrachlorideCytokinesDisease Models, AnimalDown-RegulationDrugs, Chinese HerbalHepatic Stellate CellsInflammationJanus Kinase 1LiverLiver CirrhosisMaleMAP Kinase Signaling SystemMedicine, Chinese TraditionalPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktCarbon TetrachlorideCytokinesDrugs, Chinese HerbalJanus Kinase 1Phosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSTAT3 Transcription FactorJAK1/STAT3liver fibrosisPI3K/AKTRas/ERKtraditional Chinese herbal therapyYu Gan Long

Identifiers

PMID32681257
OpenAlexW3043568399

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.