ArticleNeuroradiology2020
Multimodal validation of focal enhancement in intracranial aneurysms as a surrogate marker for aneurysm instability.
Article in Neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- A Systematic Review and Meta-Analysis of the Pathology Underlying Aneurysm Enhancement on Vessel Wall Imaging.International journal of molecular sciences · 2024Pooled it
- The association between hemodynamics and wall characteristics in human intracranial aneurysms: a review.Neurosurgical review · 2022Pooled it
- Intracranial aneurysm wall enhancement as an indicator of instability: a systematic review and meta-analysis.European journal of neurology · 2021Pooled it
- Association of hypertension and blood pressure control with aneurysm wall enhancement in unruptured intracranial aneurysms: a multicenter propensity score-matched study.European radiology · 2026Observational
- Fat-suppression performance for in-stent plaque imaging after carotid artery stenting using three-dimensional TPhysical and engineering sciences in medicine · 2026Article
- Vasa vasorum plexus formation in intracranial aneurysm associates with microcalcification and wall thickening.Science advances · 2025Article
- A Review of Intracranial Aneurysm Imaging Modalities, from CT to State-of-the-Art MR.AJNR. American journal of neuroradiology · 2025Review
- Beyond Size: Advanced MRI Breakthroughs in Predicting Intracranial Aneurysm Rupture Risk.Journal of clinical medicine · 2025Review
- Near-Wall Slow Flow Contributes to Wall Enhancement of Middle Cerebral Artery Bifurcation Aneurysms on Vessel Wall MRI.Diagnostics (Basel, Switzerland) · 2024Article
- The relationship between symptomatic status and aneurysm wall enhancement characteristics of single unruptured intracranial aneurysm.Radiologie (Heidelberg, Germany) · 2024Article
- Focal Aneurysm Wall Enhancement in Vessel Wall Imaging as a Surrogate Marker for Predicting Aneurysm Instability.Stroke (Hoboken, N.J.) · 2023Article
- Wall enhancement as a biomarker of intracranial aneurysm instability: a histo-radiological study.Acta neurochirurgica · 2023Observational
- 3D aneurysm wall enhancement is associated with symptomatic presentation.Journal of neurointerventional surgery · 2023Article
- Aneurysm wall enhancement, hemodynamics, and morphology of intracranial fusiform aneurysms.Frontiers in aging neuroscience · 2023Article
- Global tendencies and frontier topics in hemodynamics research of intracranial aneurysms: a bibliometric analysis from 1999 to 2022.Frontiers in physiology · 2023Article
- Quantitative assessment of microstructural evolution of intracranial aneurysm wall by vessel wall imaging.Neuroradiology · 2022Article
- Topographical Analysis of Aneurysm Wall Enhancement With 3-Dimensional Mapping.Stroke (Hoboken, N.J.) · 2022Article
- Intracranial aneurysm wall (in)stability-current state of knowledge and clinical perspectives.Neurosurgical review · 2022Review
- High-Resolution Vessel Wall MRI of Endovascularly Treated Intracranial Aneurysms.Tomography (Ann Arbor, Mich.) · 2022Article
- Hemodynamic Characteristic Analysis of Aneurysm Wall Enhancement in Unruptured Middle Cerebral Artery Aneurysm.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
purposeCircumferential enhancement on MR vessel wall imaging has been proposed as a biomarker of a higher risk of rupture in intracranial aneurysms. Focal enhancement is frequently encountered in unruptured aneurysms, but its implication for risk stratification and patient management remains unclear. This study investigates the association of focal wall enhancement with hemodynamic and morphological risk factors and histologic markers of wall inflammation and degeneration.
methodsPatients with an unruptured middle cerebral artery aneurysm who underwent 3D rotational angiography and 3T MR vessel wall imaging showing focal wall enhancement were included. Hemodynamic parameters were calculated based on flow simulations and compared between enhanced regions and the entire aneurysm surface. Morphological parameters were semiautomatically extracted and quantitatively associated with wall enhancement. Histological analysis included detection of vasa vasorum, CD34, and myeloperoxidase staining in a subset of patients.
resultsTwenty-two aneurysms were analyzed. Enhanced regions were significantly associated with lower AWSS, lower maxOSI, and increased LSA. In multivariate analysis, higher ellipticity index was an independent predictor of wall enhancement. Histologic signs of inflammation and degeneration and higher PHASES score were significantly associated with focal enhancement.
conclusionFocal wall enhancement is colocalized with hemodynamic factors that have been related to a higher rupture risk. It is correlated with morphological factors linked to rupture risk, higher PHASES score, and histologic markers of wall destabilization. The results support the hypothesis that focal enhancement could serve as a surrogate marker for aneurysm instability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.