ArticleThe Journal of antimicrobial chemotherapy2020
AbGRI4, a novel antibiotic resistance island in multiply antibiotic-resistant Acinetobacter baumannii clinical isolates.
Article in The Journal of antimicrobial chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Complete genome of multiply antibiotic resistant ST10Microbiology spectrum · 2026Article
- Mobilization of the AbGRI4 resistance island inMicrobiology spectrum · 2026Article
- Nested mobile genetic elements mediating antimicrobial resistance genes mobility within and betweeniScience · 2026Article
- One resistance gene, many transposons: repeated formation of compound and pseudo-compound transposons carrying the aphA1 kanamycin and neomycin resistance gene.The Journal of antimicrobial chemotherapy · 2026Article
- Lineage-Specific Associations between the Resistome and Mobilome across 10,500 Globally DistributedComputational and structural biotechnology journal · 2026Article
- Whole genome sequencing and genomic characterization of the extensively drug-resistant Acinetobacter baumannii recovered from clinical samples in Lahore, Pakistan.Molecular biology reports · 2025Article
- In Silico Identification and Molecular Characterization ofAntibiotics (Basel, Switzerland) · 2025Article
- The evolution of the multidrug-resistant and globally distributed ST2 Acinetobacter baumannii in China.BMC microbiology · 2025Article
- ISMicrobiology and molecular biology reviews : MMBR · 2024Review
- Review
- Clinical Outcomes and Bacterial Characteristics of Carbapenem-resistant Acinetobacter baumannii Among Patients From Different Global Regions.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Observational
- Occurrence of Acinetobacter baumannii genomic resistance islands (AbGRIs) in Acinetobacter baumannii strains belonging to global clone 2 obtained from COVID-19 patients.BMC microbiology · 2023Article
- Portrait of a killer: Uncovering resistance mechanisms and global spread of Acinetobacter baumannii.PLoS pathogens · 2023Article
- plASgraph2: using graph neural networks to detect plasmid contigs from an assembly graph.Frontiers in microbiology · 2023Article
- Mobile genetic elements in Acinetobacter antibiotic-resistance acquisition and dissemination.Annals of the New York Academy of Sciences · 2022Review
- Plasmids Carrying Antimicrobial Resistance Genes in Gram-Negative Bacteria.Microorganisms · 2022Article
- Origin, Phylogeny, and Transmission of the Epidemic Clone ST208 of Carbapenem-Resistant Acinetobacter baumannii on a Global Scale.Microbiology spectrum · 2022Article
- Cl415, a carbapenem-resistant Acinetobacter baumannii isolate containing four AbaR4 and a new variant of AbGRI2, represents a novel global clone 2 strain.The Journal of antimicrobial chemotherapy · 2022Article
- Comparing Long-Read Assemblers to Explore the Potential of a Sustainable Low-Cost, Low-Infrastructure Approach to Sequence Antimicrobial Resistant Bacteria With Oxford Nanopore Sequencing.Frontiers in microbiology · 2022Article
- Genetic Configuration of Genomic Resistance Islands inFrontiers in microbiology · 2022Article
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9 authors.
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Abstract
objectivesTo investigate the genomic context of a novel resistance island (RI) in multiply antibiotic-resistant Acinetobacter baumannii clinical isolates and global isolates.
methodsUsing a combination of long and short reads generated from the Oxford Nanopore and Illumina platforms, contiguous chromosomes and plasmid sequences were determined. BLAST-based analysis was used to identify the RI insertion target.
resultsGenomes of four multiply antibiotic-resistant A. baumannii clinical strains, from a US hospital system, belonging to prevalent MLST ST2 (Pasteur scheme) and ST281 (Oxford scheme) clade F isolates were sequenced to completion. A class 1 integron carrying aadB (tobramycin resistance) and aadA2 (streptomycin/spectinomycin resistance) was identified. The class 1 integron was 6.8 kb, bounded by IS26 at both ends, and embedded in a new target location between an α/β-hydrolase and a reductase. Due to its novel insertion site and unique RI composition, we suggest naming this novel RI AbGRI4. Molecular analysis of global A. baumannii isolates identified multiple AbGRI4 RI variants in non-ST2 clonal lineages, including variations in the resistance gene cassettes, integron backbone and insertion breakpoints at the hydrolase gene.
conclusionsA novel RI insertion target harbouring a class 1 integron was identified in a subgroup of ST2/ST281 clinical isolates. Variants of the RI suggested evolution and horizontal transfer of the RI across clonal lineages. Long- and short-read hybrid assembly technology completely resolved the genomic context of IS-bounded RIs, which was not possible using short reads alone.
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