Evidence map›Paper›PMID 32681112›Full record

ArticleScientific reports2020

Association of lung function with overall mortality is independent of inflammatory, cardiac, and functional biomarkers in older adults: the ActiFE-study.

Gudrun Weinmayr, Holger Schulz, Jochen Klenk, Michael Denkinger, Enric Duran-Tauleria, Wolfgang Koenig, Dhayana Dallmeier, Dietrich Rothenbacher, ActiFE Study Group

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
  5. The association between spirometry measurement quality, cognitive function, and mortality.Archives of public health = Archives belges de sante publique · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Lung Function as a Biomarker of Health: An Old Concept Rediscovered.American journal of respiratory and critical care medicine · 2023
    Article
  11. Observational
  12. Rapid FEVJournal of Korean medical science · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Genetic pleiotropy between pulmonary function and age-related traits: The Long Life Family Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 9 institutions in 4 countries.

Gudrun WeinmayrInstitute of Epidemiology and Medical Biometry, Ulm University, Helmholtzstraße 22, 89081, Ulm, Germany. Gudrun.Weinmayr@uni-ulm.de.
Holger SchulzInstitute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Jochen KlenkInstitute of Epidemiology and Medical Biometry, Ulm University, Helmholtzstraße 22, 89081, Ulm, Germany.ORCID http://orcid.org/0000-0002-5987-447X
Michael DenkingerAgaplesion Bethesda Clinic, Geriatric Research Unit, Ulm University, Ulm, Germany.
Enric Duran-TauleriaGlobal Institute of Neurodevelopment Integrated Care (IGAIN), Barcelona, Spain.
Wolfgang KoenigInstitute of Epidemiology and Medical Biometry, Ulm University, Helmholtzstraße 22, 89081, Ulm, Germany.ORCID http://orcid.org/0000-0002-2064-9603
Dhayana Dallmeier *Agaplesion Bethesda Clinic, Geriatric Research Unit, Ulm University, Ulm, Germany.
Dietrich Rothenbacher *Institute of Epidemiology and Medical Biometry, Ulm University, Helmholtzstraße 22, 89081, Ulm, Germany.ORCID http://orcid.org/0000-0002-3563-2791
ActiFE Study Group
Universität Ulm · DEAgaplesion Bethesda Klinik · DENanyang Technological University · SGBarcelona Institute for Global Health · ESGerman Centre for Cardiovascular Research · DEHelmholtz-Institute Ulm · DEHelmholtz Zentrum München · DERobert Bosch Hospital · DERWTH Aachen University · DE

Funding

Dystrophin and Heart DiseaseR01HL138490 · NHLBI · UNIVERSITY OF MINNESOTA · PI METZGER, JOSEPH MARK · 2017 to 2020
$1.5M
NIH HHS R01HL138490
6 · The paper itself

Abstract

Reduced lung function is associated with overall and cardiovascular mortality. Chronic low grade systemic inflammation is linked to impaired lung function and cardiovascular outcomes. We assessed the association of lung function with overall 8-year mortality in 867 individuals of the Activity and Function in the Elderly study using confounder-adjusted Cox proportional hazards models (including gait speed and daily walking time as measures of physical function) without and with adjustment for inflammatory and cardiac markers. Forced expiratory volume in 1 s/forced vital capacity (FEV

Indexed as

BiomarkersGeriatric AssessmentMortalityAgedAged, 80 and overComorbidityGermanyHumansLungProportional Hazards ModelsPublic Health SurveillanceRespiratory Function TestsRisk FactorsBiomarkers

Identifiers

PMID32681112
PMCPMC7367870
OpenAlexW3042633628

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.