ArticleScientific reports2020
Fluctuation relations and fitness landscapes of growing cell populations.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 25 citations in OpenAlex.
- Extremal events dictate population growth rate inference.PLoS computational biology · 2026Article
- Coupling Bacterial Cell Size Regulation with Clonal Proliferation Dynamics Reveals Cell Division Based on Surface Area.bioRxiv : the preprint server for biology · 2025Article
- Article
- Analytical cell size distribution: lineage-population bias and parameter inference.Journal of the Royal Society, Interface · 2022Article
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2 authors at 1 institution in 1 country.
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Abstract
We construct a pathwise formulation of a growing population of cells, based on two different samplings of lineages within the population, namely the forward and backward samplings. We show that a general symmetry relation, called fluctuation relation relates these two samplings, independently of the model used to generate divisions and growth in the cell population. These relations lead to estimators of the population growth rate, which can be very efficient as we demonstrate by an analysis of a set of mother machine data. These fluctuation relations lead to general and important inequalities between the mean number of divisions and the doubling time of the population. We also study the fitness landscape, a concept based on the two samplings mentioned above, which quantifies the correlations between a phenotypic trait of interest and the number of divisions. We obtain explicit results when the trait is the age or the size, for age and size-controlled models.
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