ArticleNature communications2020
BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 61 citations in OpenAlex.
- A mutational scar-based genome-wide map of DNA double-strand break repair.Nature communications · 2026Article
- Microhomology-mediated end joining acts directly on replication forks to repair single-ended double-strand breaks.Molecular cell · 2026Article
- TONSL suppresses polymerase theta-dependent tandem duplications through chromatin-guided repair.Nature communications · 2026Article
- POLQ-driven repair scars shape the immunogenic landscape of homologous recombination-deficient pancreatic cancer.bioRxiv : the preprint server for biology · 2026Article
- Damage-induced phosphorylation of BRC-1/BRD-1 in meiosis preserves germline integrity.Nucleic acids research · 2025Article
- Detecting likely germline variants during tumor-based molecular profiling.The Journal of clinical investigation · 2025Review
- Late steps of allelic break-induced replication suppress tandem duplication associated with BRCA1 deficiency.Nucleic acids research · 2025Article
- Review
- Article
- POLQ to the rescue for double-strand break repair during mitosis.Nature structural & molecular biology · 2023Article
- Meiotic DNA breaks drive multifaceted mutagenesis in the human germ line.Science (New York, N.Y.) · 2023Article
- Genetic separation of Brca1 functions reveal mutation-dependent Polθ vulnerabilities.Nature communications · 2023Article
- Regulation of gene editing using T-DNA concatenation.Nature plants · 2023Article
- Extrachromosomal circular DNA and structural variants highlight genome instability in Arabidopsis epigenetic mutants.Nature communications · 2023Article
- Experimental systems for the analysis of mutational signatures: no 'one-size-fits-all' solution.Biochemical Society transactions · 2023Article
- Polymerase θ inhibition steps on the cGAS pedal.The Journal of clinical investigation · 2023Article
- Polλ promotes microhomology-mediated end-joining.Nature structural & molecular biology · 2023Article
- Article
- Aging and sperm signals alter DNA break formation and repair in the C. elegans germline.PLoS genetics · 2022Article
- Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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Abstract
Failure to preserve the integrity of the genome is a hallmark of cancer. Recent studies have revealed that loss of the capacity to repair DNA breaks via homologous recombination (HR) results in a mutational profile termed BRCAness. The enzymatic activity that repairs HR substrates in BRCA-deficient conditions to produce this profile is currently unknown. We here show that the mutational landscape of BRCA1 deficiency in C. elegans closely resembles that of BRCA1-deficient tumours. We identify polymerase theta-mediated end-joining (TMEJ) to be responsible: knocking out polq-1 suppresses the accumulation of deletions and tandem duplications in brc-1 and brd-1 animals. We find no additional back-up repair in HR and TMEJ compromised animals; non-homologous end-joining does not affect BRCAness. The notion that TMEJ acts as an alternative to HR, promoting the genome alteration of HR-deficient cells, supports the idea that polymerase theta is a promising therapeutic target for HR-deficient tumours.
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