ArticleNeurology2020
A nationwide, retrospective, data-linkage, cohort study of epilepsy and incident dementia.
Article in Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 4 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Alzheimer Disease and Epilepsy: A Mendelian Randomization Study.Neurology · 2023Pooled it
- Pooled it
- Anti-seizure medication exposure and the risk of dementia: A meta-analysis of observational studies.Frontiers in neurology · 2023Pooled it
- Late-onset epilepsy and the risk of dementia: a systematic review and meta-analysis.Aging clinical and experimental research · 2022Pooled it
- Safety, tolerability, and efficacy outcomes of the Investigation of Levetiracetam in Alzheimer's disease (ILiAD) study: a pilot, double-blind placebo-controlled crossover trial.Epilepsia open · 2024Trial
- Tau pathology in epilepsy: emerging mechanisms and translational opportunities.Brain : a journal of neurology · 2026Review
- Will Memantine Exacerbate Seizures in People With Epilepsy? A Prospective Cohort Study.Annals of clinical and translational neurology · 2026Article
- Antiseizure Medications in Older Adults with Epilepsy: Considerations in Pharmacology, Safety, Tolerability, and Effectiveness of Newer Agents.Drugs & aging · 2026Review
- EEG features in late-onset epilepsy: possible correlation with cognitive impairment.Brain communications · 2026Article
- The association of seizure control with neuropathology in dementia.Brain : a journal of neurology · 2025Article
- The Bidirectional Relationship Between Epilepsy and Alzheimer's Disease.Current neurology and neuroscience reports · 2025Review
- Epilepsy and brain health: a large prospective cohort study.Journal of translational medicine · 2024Article
- Association of Seizure Control With Cognition in People With Normal Cognition and Mild Cognitive Impairment.Neurology · 2024Article
- Traumatic Brain Injury, Seizures, and Cognitive Impairment Among Older Adults.JAMA network open · 2024Article
- Alzheimer's Disease and Epilepsy: Exploring Shared Pathways and Promising Biomarkers for Future Treatments.Journal of clinical medicine · 2024Review
- Associations Between Neuroinflammation-Related Conditions and Alzheimer's Disease: A Study of US Insurance Claims Data.Journal of Alzheimer's disease : JAD · 2024Article
- Increasing Risk of Dementia Among Patients with Subsequent Epilepsy Within 2 Years Post-Traumatic Brain Injury: A Population-Based Case-Control Study.Journal of multidisciplinary healthcare · 2024Article
- Chemogenetic inhibition of subicular seizure-activated neurons alleviates cognitive deficit in male mouse epilepsy model.Acta pharmacologica Sinica · 2023Article
- Association of Plasma AβNeurology · 2023Article
- Comorbidity among inpatients with dementia: a preliminary cross-sectional study in West China.Aging clinical and experimental research · 2023Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo determine the association of epilepsy with incident dementia by conducting a nationwide, retrospective data-linkage, cohort study to examine whether the association varies according to dementia subtypes and to investigate whether risk factors modify the association.
methodsWe used linked health data from hospitalization, mortality records, and primary care consultations to follow up 563,151 Welsh residents from their 60th birthday to estimate dementia rate and associated risk factors. Dementia, epilepsy, and covariates (medication, smoking, comorbid conditions) were classified with the use of previously validated code lists. We studied rate of dementia and dementia subtypes in people with epilepsy (PWE) and without epilepsy using (stratified) Kaplan-Meier plots and flexible parametric survival models.
resultsPWE had a 2.5 (95% confidence interval [CI] 2.3-2.6) times higher hazard of incident dementia, a 1.6 (95% CI 1.4-1.8) times higher hazard of incident Alzheimer disease (AD), and a 3.1 (95% CI 2.8-3.4) times higher hazard of incident Vascular dementia (VaD). A history of stroke modified the increased incidence in PWE. PWE who were first diagnosed at ≤25 years of age had a dementia rate similar to that of those diagnosed later in life. PWE who had ever been prescribed sodium valproate compared to those who had not were at higher risk of dementia (hazard ratio [HR] 1.6, 99% CI 1.4-1.9) and VaD (HR 1.7, 99% CI 1.4-2.1) but not AD (HR 1.2, 99% CI 0.9-1.5).
conclusionPWE compared to those without epilepsy have an increased dementia risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.