ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Spontaneous Retinal Waves Can Generate Long-Range Horizontal Connectivity in Visual Cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 28 citations in OpenAlex.
- A single computational objective can produce specialization of streams in visual cortex.Nature communications · 2026Article
- Recurrent connections facilitate occluded object recognition by explaining-away.Nature communications · 2026Article
- Retinal waves reveal axial biases in modular patterns of cortical activity that predict future orientation preferences.bioRxiv : the preprint server for biology · 2025Article
- Relationship between functional structures and horizontal connections in macaque inferior temporal cortex.Scientific reports · 2025Article
- A unifying framework for functional organization in early and higher ventral visual cortex.Neuron · 2024Article
- Emergence of input selective recurrent dynamics via information transfer maximization.Scientific reports · 2024Article
- Self-organization of modular activity in immature cortical networks.Nature communications · 2024Article
- Species-specific wiring of cortical circuits for small-world networks in the primary visual cortex.PLoS computational biology · 2023Article
- Cortical topographic motifs emerge in a self-organized map of object space.Science advances · 2023Article
- A Unifying Principle for the Functional Organization of Visual Cortex.bioRxiv : the preprint server for biology · 2023Article
- Invariance of object detection in untrained deep neural networks.Frontiers in computational neuroscience · 2022Article
- Unification of free energy minimization, spatiotemporal energy, and dimension reduction models of V1 organization: Postnatal learning on an antenatal scaffold.Frontiers in computational neuroscience · 2022Article
- Visual number sense in untrained deep neural networks.Science advances · 2021Article
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the primary visual cortex (V1) of higher mammals, long-range horizontal connections (LHCs) are observed to develop, linking iso-orientation domains of cortical tuning. It is unknown how this feature-specific wiring of circuitry develops before eye-opening. Here, we suggest that LHCs in V1 may originate from spatiotemporally structured feedforward activities generated from spontaneous retinal waves. Using model simulations based on the anatomy and observed activity patterns of the retina, we show that waves propagating in retinal mosaics can initialize the wiring of LHCs by coactivating neurons of similar tuning, whereas equivalent random activities cannot induce such organizations. Simulations showed that emerged LHCs can produce the patterned activities observed in V1, matching the topography of the underlying orientation map. The model can also reproduce feature-specific microcircuits in the salt-and-pepper organizations found in rodents. Our results imply that early peripheral activities contribute significantly to cortical development of functional circuits.
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