Evidence map›Paper›PMID 32680929›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2021

Automated Segmentation of Baseline Metabolic Total Tumor Burden in Diffuse Large B-Cell Lymphoma: Which Method Is Most Successful? A Study on Behalf of the PETRA Consortium.

Sally F Barrington, Ben G J C Zwezerijnen, Henrica C W de Vet, Martijn W Heymans, N George Mikhaeel, Coreline N Burggraaff, Jakoba J Eertink, Lucy C Pike, Otto S Hoekstra, Josée M Zijlstra and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 108 citations in OpenAlex.

  1. Malignancy Detection Rates of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
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  4. Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
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  7. Validation of an AI Method for Automated Lymphoma Metabolic Tumor Volume Segmentation Using a Public Benchmark PET/CT Dataset.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
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  8. Review
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  10. Artificial intelligence for TNM staging in NSCLC: a critical appraisal of segmentation utility in [European journal of nuclear medicine and molecular imaging · 2026
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  12. [European journal of nuclear medicine and molecular imaging · 2026
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  15. Can we obtain prognostic information from healthy tissue uptake and volume in baselineEuropean journal of nuclear medicine and molecular imaging · 2026
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  17. Article
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  19. Integration of [Leukemia · 2025
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  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Sally F BarringtonKing's College London and Guy's and St. Thomas' PET Center, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom sally.barrington@kcl.ac.uk.
Ben G J C ZwezerijnenDepartment of Radiology and Nuclear Medicine, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Henrica C W de VetDepartment of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Martijn W HeymansDepartment of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
N George MikhaeelDepartment of Clinical Oncology, Guy's and St. Thomas' NHS Foundation Trust and School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom; and.
Coreline N BurggraaffDepartment of Hematology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Jakoba J EertinkDepartment of Hematology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Lucy C PikeKing's College London and Guy's and St. Thomas' PET Center, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
Otto S HoekstraDepartment of Radiology and Nuclear Medicine, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Josée M ZijlstraDepartment of Hematology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Ronald BoellaardDepartment of Radiology and Nuclear Medicine, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Amsterdam University Medical Centers · NLKing's College London · GBVrije Universiteit Amsterdam · NL

Funding

Cancer Research UKDepartment of Health RP-2016-07-001
6 · The paper itself

Abstract

Metabolic tumor volume (MTV) is a promising biomarker of pretreatment risk in diffuse large B-cell lymphoma (DLBCL). Different segmentation methods can be used that predict prognosis equally well but give different optimal cutoffs for risk stratification. Segmentation can be cumbersome; a fast, easy, and robust method is needed. Our aims were to evaluate the best automated MTV workflow in DLBCL; determine whether uptake time, compliance or noncompliance with standardized recommendations for

Indexed as

Positron Emission Tomography Computed TomographyTumor BurdenAdultAutomationFemaleHumansImage Processing, Computer-AssistedLymphoma, Large B-Cell, DiffuseMaleMiddle Agedlymphomametabolic tumor volumePETstandardization

Identifiers

PMID32680929
PMCPMC8049348
OpenAlexW3043558719

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.