Evidence map›Paper›PMID 32680919›Full record

ArticleMolecular pharmacology2020

Atomic-Level Characterization of the Methadone-Stabilized Active Conformation of

Abhijeet Kapoor, Davide Provasi, Marta Filizola

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Molecular pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Abhijeet KapoorDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.ORCID 0000-0002-3606-3463
Davide ProvasiDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.ORCID 0000-0002-2868-303X
Marta FilizolaDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York marta.filizola@mssm.edu.ORCID 0000-0002-4382-8276
Icahn School of Medicine at Mount Sinai · US

Funding

Breakthrough Molecular Dynamics Research via an Anton2 SupercomputerR01GM116961 · NIGMS · CARNEGIE-MELLON UNIVERSITY · PI BLOOD, PHILIP D. · 2016 to 2023
$3.0M
Molecular and Dynamic Insights into the Function of GPCRs Involved in Drug AbuseR01DA045473 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FILIZOLA, MARTA · 2018 to 2022
$2.2M
Big Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0M
Transforming Genomics with 5 PB Big Omics Data Engine Cray CS300-AC SupercomputerS10OD018522 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2014 to 2014
$1.9M
NIDA NIH HHS R01 DA045473NIGMS NIH HHS R01 GM116961NIH HHS S10 OD018522NIH HHS S10 OD026880
6 · The paper itself

Abstract

Methadone is a synthetic opioid agonist with notoriously unique properties, such as lower abuse liability and induced relief of withdrawal symptoms and drug cravings, despite acting on the same opioid receptors triggered by classic opioids-in particular the

Indexed as

Analgesics, OpioidAnimalsBinding SitesEntropyHumansMarkov ChainsMethadoneMiceModels, MolecularMolecular Dynamics SimulationProtein BindingProtein ConformationReceptors, Opioid, muSpiro CompoundsThiophenes((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amineAnalgesics, OpioidMethadoneReceptors, Opioid, muSpiro CompoundsThiophenes

Identifiers

PMID32680919
PMCPMC7562981
OpenAlexW3042338130

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.