Evidence map›Paper›PMID 32680830›Full record

ArticleDiabetes care2020

Cardiovascular Determinants of Aerobic Exercise Capacity in Adults With Type 2 Diabetes.

Gaurav S Gulsin, Joseph Henson, Emer M Brady, Jack A Sargeant, Emma G Wilmot, Lavanya Athithan, Zin Z Htike, Anna-Marie Marsh, John D Biglands, Peter Kellman and 5 more

Abstract read
In one paragraph

Article in Diabetes care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  13. Association between subclinical right ventricular alterations and aerobic exercise capacity in type 2 diabetes.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2024
    Article
  14. Association between coronary microvascular dysfunction and exercise capacity in dilated cardiomyopathy.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2024
    Article
  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Gaurav S GulsinDepartment of Cardiovascular Sciences, University of Leicester and the NIHR Leicester Biomedical Research Centre, Leicester, U.K. gpm12@leicester.ac.uk.ORCID 0000-0002-1740-9270
Joseph HensonDiabetes Research Centre, University of Leicester and the NIHR Leicester Biomedical Research Centre, Leicester, U.K.
Emer M BradyDepartment of Cardiovascular Sciences, University of Leicester and the NIHR Leicester Biomedical Research Centre, Leicester, U.K.
Jack A SargeantDiabetes Research Centre, University of Leicester and the NIHR Leicester Biomedical Research Centre, Leicester, U.K.ORCID 0000-0003-0395-7329
Emma G WilmotDiabetes Department, Royal Derby Hospital, University Hospitals of Derby and Burton NHS Foundation Trust, Derby, U.K.
Lavanya AthithanDepartment of Cardiovascular Sciences, University of Leicester and the NIHR Leicester Biomedical Research Centre, Leicester, U.K.
Zin Z HtikeDiabetes Department, Royal Derby Hospital, University Hospitals of Derby and Burton NHS Foundation Trust, Derby, U.K.ORCID 0000-0003-2032-8938
Anna-Marie MarshDepartment of Cardiovascular Sciences, University of Leicester and the NIHR Leicester Biomedical Research Centre, Leicester, U.K.
John D BiglandsNIHR Leeds Biomedical Research Centre, Leeds, U.K.
Peter KellmanNational Heart, Lung, and Blood Institute, Bethesda, MD.
Kamlesh KhuntiDiabetes Research Centre, University of Leicester and the NIHR Leicester Biomedical Research Centre, Leicester, U.K.ORCID 0000-0002-3932-3339
David WebbDiabetes Research Centre, University of Leicester and the NIHR Leicester Biomedical Research Centre, Leicester, U.K.ORCID 0000-0003-2343-7099
Melanie J DaviesDiabetes Research Centre, University of Leicester and the NIHR Leicester Biomedical Research Centre, Leicester, U.K.
Thomas YatesDiabetes Research Centre, University of Leicester and the NIHR Leicester Biomedical Research Centre, Leicester, U.K.
Gerry P McCannDepartment of Cardiovascular Sciences, University of Leicester and the NIHR Leicester Biomedical Research Centre, Leicester, U.K. gpm12@leicester.ac.uk.

Funding

British Heart Foundation FS/16/47/32190British Heart Foundation FS/18/26/33501Department of Health ICA-CL-2016-02-017Department of Health RP-2017-08-ST2-007
6 · The paper itself

Abstract

objectiveTo assess the relationship between subclinical cardiac dysfunction and aerobic exercise capacity (peak VO RESEARCH DESIGN AND

methodsCross-sectional study. We prospectively enrolled a multiethnic cohort of asymptomatic adults with T2D and no history, signs, or symptoms of cardiovascular disease. Age-, sex-, and ethnicity-matched control subjects were recruited for comparison. Participants underwent bioanthropometric profiling, cardiopulmonary exercise testing, and cardiovascular magnetic resonance with adenosine stress perfusion imaging. Multivariable linear regression analysis was undertaken to identify independent associations between measures of cardiovascular structure and function and peak VO

resultsA total of 247 adults with T2D (aged 51.8 ± 11.9 years, 55% males, 37% black or south Asian ethnicity, HbA

conclusionsIn a multiethnic cohort of asymptomatic people with T2D, MPR and diastolic function are key determinants of aerobic exercise capacity, independent of age, sex, ethnicity, smoking status, or blood pressure.

Indexed as

AdultAgedAsymptomatic DiseasesCardiovascular SystemCase-Control StudiesCohort StudiesCross-Sectional StudiesDiabetes Mellitus, Type 2Diabetic AngiopathiesDiastoleExerciseExercise TestExercise ToleranceFemaleHumansLung Volume Measurements

Identifiers

PMID32680830
PMCPMC7440912

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.