Evidence map›Paper›PMID 32680649›Full record

ReviewTrends in cancer2020

Improving Bioprinted Volumetric Tumor Microenvironments In Vitro.

Jun Li, Carolina Parra-Cantu, Zongyi Wang, Yu Shrike Zhang

Abstract readReview
In one paragraph

Review in Trends in cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. A 3D-Bioprinted Multiple Myeloma Model.Advanced healthcare materials · 2022
    Article
  9. Review
  10. Review
  11. Frontiers in oncology · 2022
    Review
  12. Emerging Technologies in Multi-Material Bioprinting.Advanced materials (Deerfield Beach, Fla.) · 2021
    Review
  13. Article
  14. Review
  15. Senescence under appraisal: hopes and challenges revisited.Cellular and molecular life sciences : CMLS · 2021
    Review
  16. Organ-on-a-Chip: A New Paradigm for Drug Development.Trends in pharmacological sciences · 2021
    Review
  17. Advanced Multi-Dimensional Cellular Models as Emerging Reality to ReproduceInternational journal of molecular sciences · 2021
    Review
  18. Old Stars and New Players in the Brain Tumor Microenvironment.Frontiers in cellular neuroscience · 2021
    Review
  19. Review
  20. Modeling the Leukemia MicroenviromentFrontiers in oncology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jun LiDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.
Carolina Parra-CantuDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.
Zongyi WangDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.
Yu Shrike ZhangDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA. Electronic address: yszhang@research.bwh.harvard.edu.

Funding

High-Throughput Volumetric Photoacoustic Imaging of Living Vascularized OrganoidsR01EB028143 · NIBIB · DUKE UNIVERSITY · PI YAO, JUNJIE · 2019 to 2022
$2.0M
Handheld Wound Analyzer for in situ HealingR01GM134036 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI ZHANG, Y. SHRIKE · 2020 to 2023
$1.4M
Recapitulating Ductal Carcinoma on a Chip for Personalized Breast Cancer TherapyR00CA201603 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ZHANG, Y. SHRIKE · 2019 to 2021
$747k
Multiscale Stereolithogrphic Bioprinting of Stage-Matching Vascularized Tumor ModelsR21EB025270 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI ZHANG, Y. SHRIKE · 2018 to 2020
$726k
Developing Hybrids of Cardiac Tissue and Biodegradable Electronics Towards Heart Implants with On-line Monitoring and Stimulating FunctionsR21EB026175 · NIBIB · UNIVERSITY OF HOUSTON · PI YU, CUNJIANG · 2018 to 2019
$468k
Recapitulating Ductal Carcinoma on a Chip for Personalized Breast Cancer TherapyK99CA201603 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ZHANG, Y. SHRIKE · 2016 to 2017
$356k
On-Chip Expansion MicroscopyR03EB027984 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI ZHANG, Y. SHRIKE · 2020 to 2021
$179k
NCI NIH HHS K99 CA201603NCI NIH HHS R00 CA201603NIBIB NIH HHS R01 EB028143NIBIB NIH HHS R03 EB027984NIBIB NIH HHS R21 EB025270NIBIB NIH HHS R21 EB026175NIGMS NIH HHS R01 GM134036
6 · The paper itself

Abstract

Despite the great breakthroughs in the past few decades in illuminating the pathological mechanisms of cancer and in developing new anticancer drugs, it remains extremely challenging to cure most cancers. Therefore, it is imperative to develop more sophisticated and more biomimetic preclinical cancer models. 3D models combined with dynamic culture techniques show great potential to accurately emulate the volumetric tumor microenvironment (TME). Here we introduce advances in bioprinting technologies for in vitro cancer modeling and their applications. Finally, we look ahead to the remaining challenges associated with current bioprinting strategies for achieving faithful cancer modeling.

Indexed as

Printing, Three-DimensionalTumor MicroenvironmentAnimalsBioprintingBiopsyCell Culture TechniquesDrug Screening Assays, AntitumorHumansNeoplasmsTissue EngineeringTumor Cells, Cultured3D modelsbioprintingcancertumor microenvironmenttumor on a chip

Identifiers

PMID32680649
PMCPMC7483398

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.