ArticleParticle and fibre toxicology2020
Oral toxicity of titanium dioxide P25 at repeated dose 28-day and 90-day in rats.
Article in Particle and fibre toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- Hydrogel-based strategies for dentin-pulp complex regeneration: a comprehensive review.Cell and tissue banking · 2026Review
- Plasma-Assisted Synthesis of TiOMolecules (Basel, Switzerland) · 2025Article
- Nanotechnology Meets Phytotherapy: A Cutting-Edge Approach to Treat Bacterial Infections.International journal of molecular sciences · 2025Review
- Hepatotoxicity of titanium dioxide nanoparticles.Journal of applied toxicology : JAT · 2025Review
- Oral toxicological study of titanium dioxide nanoparticles with a crystallite diameter of 6 nm in rats.Particle and fibre toxicology · 2023Article
- Application of transgenic zebrafish for investigating inflammatory responses to nanomaterials: Recommendations for new users.F1000Research · 2023Review
- Toxicokinetics, dose-response, and risk assessment of nanomaterials: Methodology, challenges, and future perspectives.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2022Review
- Adverse Outcome Pathways Associated with the Ingestion of Titanium Dioxide Nanoparticles-A Systematic Review.Nanomaterials (Basel, Switzerland) · 2022Review
- Reproductive and developmental toxicity screening test of new TiO2 GST in Sprague-Dawley rats.Environmental analysis, health and toxicology · 2022Article
- Repeated-dose 90-day oral toxicity study of GST in Sprague-Dawley rats.Environmental analysis, health and toxicology · 2022Article
- Ingested Engineered Nanomaterials Affect the Expression of Mucin Genes-An In Vitro-In Vivo Comparison.Nanomaterials (Basel, Switzerland) · 2021Article
- Titanium dioxide particles from the diet: involvement in the genesis of inflammatory bowel diseases and colorectal cancer.Particle and fibre toxicology · 2021Review
- Safety assessment of titanium dioxide (E171) as a food additive.EFSA journal. European Food Safety Authority · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNanotechnology is indispensable to many different applications. Although nanoparticles have been widely used in, for example, cosmetics, sunscreen, food packaging, and medications, they may pose human safety risks associated with nanotoxicity. Thus, toxicity testing of nanoparticles is essential to assess the relative health risks associated with consumer exposure.
methodsIn this study, we identified the NOAEL (no observed adverse effect level) of the agglomerated/aggregated TiO
resultsNo systemic toxicological effects were associated with the agglomerated/aggregated TiO
conclusionSubacute and subchronic oral administration of the agglomerated/aggregated TiO
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.