ArticleBMC urology2020
Circulating sex hormone levels in relation to male sperm quality.
Article in BMC urology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 50 citations in OpenAlex.
- Testicular histopathology and its association with germ cell numbers, serum concentrations of reproductive hormones, and semen quality.Andrology · 2026Article
- Effectiveness of clomiphene citrate on total motile sperm count and hormonal profile in men with clinical infertility.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2026Article
- Sperm quality parameters of Swiss army recruits pre- and peri-COVID-19: a cross-sectional, comparative analysis.New microbes and new infections · 2026Article
- Article
- Effects of High-dose Radioactive Iodine Therapy on Hormonal Profiles and Sperm Quality in Thyroidectomy Patients.Molecular imaging and radionuclide therapy · 2026Article
- Coenzyme Q10 protects against glyphosate-based herbicide-induced testicular and sperm toxicity by modulating Nrf2/Keap1/HO-1 and TLR4/NF-κB pathways.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Epidemiological characteristics and temporal trends of male infertility in Egypt (2012-2022): Analysis of 3,037 consecutive cases.Arab journal of urology · 2026Article
- Observational
- Impact of conventional cigarette and electronic cigarette use on sperm quality and IVF/ICSI outcomes.Scientific reports · 2025Article
- Article
- Luteinizing Hormone Regulates Testosterone Production, Leydig Cell Proliferation, Differentiation, and Circadian Rhythm During Spermatogenesis.International journal of molecular sciences · 2025Review
- Association of Kisspeptin and KISSReproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Alleviating doxorubicin-induced reproductive toxicity: protective and androgenic effects of drone larvae on sperm morphology and hormonal balance.Toxicological research · 2025Article
- Effects of Heat Stress-Induced Sex Hormone Dysregulation on Reproduction and Growth in Male Adolescents and Beneficial Foods.Nutrients · 2024Review
- Urinary haloacetic acid concentrations in relation to sex and thyroid hormones among reproductive-aged men.Environment international · 2024Article
- Article
- Relationship between inflammatory markers, hormonal profiles, and sperm parameters.Northern clinics of Istanbul · 2024Article
- Samarcandin protects against testicular ischemia/reperfusion injury in rats via activation of Nrf2/HO-1-mediated antioxidant responses.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Article
- Apocynin Ameliorates Monosodium Glutamate Induced Testis Damage by Impaired Blood-Testis Barrier and Oxidative Stress Parameters.Life (Basel, Switzerland) · 2023Article
- Sperm quality impairment in males of couples with pregnancy loss is correlated with sexual dysfunction: a cross-sectional study.Reproductive biology and endocrinology : RB&E · 2023Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAlthough sex hormones play critical roles in spermatogenesis and sperm maturation, it remains inconclusive whether circulating sex hormones can serve as non-invasive biomarkers to improve the assessment of sperm quality.
methodsWe systematically evaluated the association of various sex hormones in serum with sperm quality among 338 men in subfertile couples. Concentrations of luteinizing hormone (LH), follicle-stimulating hormone (FSH), total testosterone (TT), total estradiol (E2), and sex hormone-binding globulin (SHBG) were detected by chemiluminescent immunoassay. Free testosterone and estradiol were calculated using a validated algorithm. A generalized liner regression model controlling for lifestyle factors was used to evaluate the associations with sperm count, concentration, motility, and morphology.
resultsAfter adjusting for age, body mass index, current smoking and alcohol drinking, LH, FSH, and TT levels were all inversely associated with sperm motility (all P for trend < 0.05); however, in mutual adjustment analysis, only LH remained an inverse association with sperm motility after adjusting for FSH and TT levels (P for trend = 0.04). Higher concentrations of LH were also associated with lower sperm progressive motility (P for trend = 0.04). Moreover, LH and FSH levels were both inversely associated with normal sperm morphology (P for trend = 0.04 and 0.02, respectively).
conclusionsIncreased levels of LH are associated with poor sperm motility and morphology, suggesting that LH may play a central role in sperm maturation. Future studies are warranted to assess potential clinical utility of LH for risk stratification and tailed prevention of male infertility.
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