Observational studyBMC anesthesiology2020
Fluid expansion improve ventriculo-arterial coupling in preload-dependent patients: a prospective observational study.
Observational study in BMC anesthesiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Fluid challenge in critically ill patients receiving haemodynamic monitoring: a systematic review and comparison of two decades.Critical care (London, England) · 2022Pooled it
- Aerobic Training Attenuates Differences Between Black and White Adults in Left Ventricular-Vascular Coupling and Wasted Pressure Effort.Journal of the American Heart Association · 2024Trial
- Optimizing left ventricular-arterial coupling during the initial resuscitation in septic shock - a pilot prospective randomized study.BMC anesthesiology · 2022Trial
- A pilot study of the effect of norepinephrine dose on left ventricular-arterial coupling in patients with septic shock.Scientific reports · 2026Article
- Predictive value of ventriculo-arterial coupling for hypotension after induction of anaesthesia: a prospective observational cohort study.Intensive care medicine experimental · 2026Article
- Monitoring systemic ventriculoarterial coupling after cardiac surgery using continuous transoesophageal echocardiography and deep learning.Journal of clinical monitoring and computing · 2026Article
- Capillary refill time changes are associated with Vascular Waterfall response in post-cardiac surgery patients.Annals of intensive care · 2026Article
- Hemodynamic effects of volume expansion on left ventricular-arterial interactions in circulatory shock-a prospective observational study.Frontiers in cardiovascular medicine · 2026Article
- Echocardiography in the Ventilated Patient: What the Clinician Has to Know.Journal of clinical medicine · 2024Review
- Commentary: Ventriculo-arterial (un)coupling in septic shock: impact of current and upcoming hemodynamic drugs.Frontiers in cardiovascular medicine · 2023Article
- Ventriculo-arterial coupling: from physiological concept to clinical application in peri-operative care and ICUs.European journal of anaesthesiology and intensive care · 2022Review
- Ventriculo-Arterial Coupling Is Associated With Oxygen Consumption and Tissue Perfusion in Acute Circulatory Failure.Frontiers in cardiovascular medicine · 2022Article
- Role of Electromechanical Dyssynchrony Assessment During Acute Circulatory Failure and Its Relation to Ventriculo-Arterial Coupling.Frontiers in cardiovascular medicine · 2022Article
- Left ventricular-arterial coupling as a predictor of stroke volume response to norepinephrine in septic shock - a prospective cohort study.BMC anesthesiology · 2021Article
- Echocardiographic measure of dynamic arterial elastance predict pressure response during norepinephrine weaning: an observational study.Scientific reports · 2021Observational
- Oral Water Has Cardiovascular Effects Up to 60 min in Shock Patients.Frontiers in cardiovascular medicine · 2021Article
- Arterial Load and Norepinephrine Are Associated With the Response of the Cardiovascular System to Fluid Expansion.Frontiers in physiology · 2021Article
- Dynamic Arterial Elastance Is Associated With the Vascular Waterfall in Patients Treated With Norepinephrine: An Observational Study.Frontiers in physiology · 2021Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe objectives of the present study was to evaluate the effect of fluid challenge (FC) on ventriculo-arterial (V-A) coupling, its determinants: arterial elastance and ventricular elastance, and ability to predict fluid responsiveness.
methodsThirty patients admitted to cardio-thoracic ICU in whom the physician decided to perform FC were included. Arterial pressure, cardiac output, arterial elastance, and ventricular elastance, were measured before and after FC with 500 ml of lactated Ringer's solution. Fluid responders were defined as patients with more than a 15% increase in stroke volume. V-A coupling was evaluated by the arterial elastance to ventricular elastance ratio.
resultsTwenty-three (77%) of the 30 patients included in the study were fluid responders. Before FC, responders had higher arterial elastance and arterial elastance to ventricular elastance ratio. FC significantly increased mean arterial pressure, stroke volume and cardiac output, and significantly decreased systemic vascular resistance, arterial elastance and consequently the arterial elastance to ventricular elastance ratio. Changes in arterial elastance were correlated with changes in stroke volume, systemic vascular resistance, and arterial compliance. Baseline arterial elastance to ventricular elastance ratio over 1.4 predicted fluid responsiveness (area under the curve [95% confidence interval]: 0.84 [0.66-1]; p < 0.0001).
conclusionsFluid responsiveness patients had V-A coupling characterized by increase arterial elastance to ventricular elastance ratio, in relation to an increase arterial elastance. Fc improved the V-A coupling ratio by decreasing arterial elastance without altering ventricular elastance. Arterial elastance changes were related to those of systemic vascular resistance (continue component) and of arterial compliance (pulsatile component).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.